Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption

TY - JOUR

T1 - Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption

AU - Sørensen, Mette G

AU - Henriksen, Kim

AU - Neutzsky-Wulff, Anita V

AU - Dziegiel, Morten Hanefeld

AU - Karsdal, Morten A

PY - 2007/10

Y1 - 2007/10

N2 - Dissolution of the inorganic phase of bone by the osteoclasts mediated by V-ATPase and ClC-7 is a prerequisite for bone resorption. Inhibitors of osteoclastic V-ATPase or ClC-7 are novel approaches for inhibition of osteoclastic bone resorption. By testing natural compounds in acidification assays, diphyllin was identified. We characterized diphyllin with respect to the pharmacological effects on osteoclasts.

AB - Dissolution of the inorganic phase of bone by the osteoclasts mediated by V-ATPase and ClC-7 is a prerequisite for bone resorption. Inhibitors of osteoclastic V-ATPase or ClC-7 are novel approaches for inhibition of osteoclastic bone resorption. By testing natural compounds in acidification assays, diphyllin was identified. We characterized diphyllin with respect to the pharmacological effects on osteoclasts.

KW - Acids

KW - Adrenal Medulla

KW - Animals

KW - Biological Transport

KW - Bone Resorption

KW - Cattle

KW - Cell Survival

KW - Cells, Cultured

KW - Dioxolanes

KW - Enzyme Inhibitors

KW - Humans

KW - Hydrogen-Ion Concentration

KW - Lignans

KW - Molecular Structure

KW - Osteoclasts

KW - Vacuolar Proton-Translocating ATPases

U2 - 10.1359/jbmr.070613

DO - 10.1359/jbmr.070613

M3 - Journal article

C2 - 17576165

SN - 0884-0431

VL - 22

SP - 1640

EP - 1648

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

IS - 10

ER -