Diffusion tensor imaging during recovery from severe traumatic brain injury and relation to clinical outcome: a longitudinal study

TY - JOUR

T1 - Diffusion tensor imaging during recovery from severe traumatic brain injury and relation to clinical outcome: a longitudinal study

AU - Sidaros, Annette Skræp

AU - Engberg, A.W.

AU - Sidaros, Karam Michel Messiha

AU - Liptrot, Matthew George

AU - Herning, M.

AU - Petersen, Palle

AU - Paulson, Olaf B.

AU - Jernigan, Terry Lynne

AU - Rostrup, E.

AU - Sidaros, Annette

AU - Engberg, Aase W

AU - Sidaros, Karam

AU - Liptrot, Matthew G

AU - Herning, Margrethe

AU - Petersen, Palle

AU - Paulson, Olaf B

AU - Jernigan, Terry L

AU - Rostrup, Egill

PY - 2008

Y1 - 2008

N2 - Diffusion tensor imaging (DTI) has been proposed as a sensitive biomarker of traumatic white matter injury, which could potentially serve as a tool for prognostic assessment and for studying microstructural changes during recovery from traumatic brain injury (TBI). However, there is a lack of longitudinal studies on TBI that follow DTI changes over time and correlate findings with long-term clinical outcome. We performed a prospective longitudinal study of 30 adult patients admitted for subacute rehabilitation following severe traumatic brain injury. DTI and conventional MRI were acquired at mean 8 weeks (5-11 weeks), and repeated in 23 of the patients at mean 12 months (9-15 months) post-trauma. Using a region-of-interest-based approach, DTI parameters were compared to those of healthy matched controls, scanned during the same time period and rescanned with a similar interval as that of patients. At the initial scan, fractional anisotropy was reduced in all the investigated white matter regions in patients compared to controls (P

AB - Diffusion tensor imaging (DTI) has been proposed as a sensitive biomarker of traumatic white matter injury, which could potentially serve as a tool for prognostic assessment and for studying microstructural changes during recovery from traumatic brain injury (TBI). However, there is a lack of longitudinal studies on TBI that follow DTI changes over time and correlate findings with long-term clinical outcome. We performed a prospective longitudinal study of 30 adult patients admitted for subacute rehabilitation following severe traumatic brain injury. DTI and conventional MRI were acquired at mean 8 weeks (5-11 weeks), and repeated in 23 of the patients at mean 12 months (9-15 months) post-trauma. Using a region-of-interest-based approach, DTI parameters were compared to those of healthy matched controls, scanned during the same time period and rescanned with a similar interval as that of patients. At the initial scan, fractional anisotropy was reduced in all the investigated white matter regions in patients compared to controls (P

KW - Adolescent

KW - Adult

KW - Aged

KW - Anisotropy

KW - Brain Injuries

KW - Brain Injury, Chronic

KW - Brain Mapping

KW - Corpus Callosum

KW - Diffusion Magnetic Resonance Imaging

KW - Female

KW - Glasgow Outcome Scale

KW - Humans

KW - Longitudinal Studies

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Neuronal Plasticity

KW - Prognosis

KW - Prospective Studies

KW - Tegmentum Mesencephali

U2 - 10.1093/brain/awm294

DO - 10.1093/brain/awm294

M3 - Journal article

C2 - 18083753

SN - 0006-8950

VL - 131

SP - 559

EP - 572

JO - Brain

JF - Brain

IS - Pt 2

ER -