@article{71613ce0064d11deb05e000ea68e967b,
title = "Diffusion tensor imaging during recovery from severe traumatic brain injury and relation to clinical outcome: a longitudinal study",
abstract = "Diffusion tensor imaging (DTI) has been proposed as a sensitive biomarker of traumatic white matter injury, which could potentially serve as a tool for prognostic assessment and for studying microstructural changes during recovery from traumatic brain injury (TBI). However, there is a lack of longitudinal studies on TBI that follow DTI changes over time and correlate findings with long-term clinical outcome. We performed a prospective longitudinal study of 30 adult patients admitted for subacute rehabilitation following severe traumatic brain injury. DTI and conventional MRI were acquired at mean 8 weeks (5-11 weeks), and repeated in 23 of the patients at mean 12 months (9-15 months) post-trauma. Using a region-of-interest-based approach, DTI parameters were compared to those of healthy matched controls, scanned during the same time period and rescanned with a similar interval as that of patients. At the initial scan, fractional anisotropy was reduced in all the investigated white matter regions in patients compared to controls (P ",
keywords = "Adolescent, Adult, Aged, Anisotropy, Brain Injuries, Brain Injury, Chronic, Brain Mapping, Corpus Callosum, Diffusion Magnetic Resonance Imaging, Female, Glasgow Outcome Scale, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Neuronal Plasticity, Prognosis, Prospective Studies, Tegmentum Mesencephali",
author = "Sidaros, {Annette Skr{\ae}p} and A.W. Engberg and Sidaros, {Karam Michel Messiha} and Liptrot, {Matthew George} and M. Herning and Palle Petersen and Paulson, {Olaf B.} and Jernigan, {Terry Lynne} and E. Rostrup and Annette Sidaros and Engberg, {Aase W} and Karam Sidaros and Liptrot, {Matthew G} and Margrethe Herning and Palle Petersen and Paulson, {Olaf B} and Jernigan, {Terry L} and Egill Rostrup",
year = "2008",
doi = "10.1093/brain/awm294",
language = "English",
volume = "131",
pages = "559--72",
journal = "Brain",
issn = "0006-8950",
publisher = "Oxford University Press",
number = "Pt 2",
}