Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells: [Plus] Corrigendum

Martin Hölzer; Verena Krähling; Fabian Amman; Emanuel Barth; Stephan H. Bernhart; Victor Adriano Okstoft Carmelo; Maximilian Collatz; Gero Doose; Florian Eggenhofer; Jan Ewald; Jörg Fallmann; Lasse M. Feldhahn; Markus Fricke; Juliane Gebauer; Andreas J. Gruber; Franziska Hufsky; Henrike Indrischek; Sabina Kanton; Jörg Linde; Nelly Mostajo; Roman Ochsenreiter; Konstantin Riege; Lorena Rivarola-Duarte; Abdullah H. Sahyoun; Sita J. Saunders; Ernst Stefan Seemann; Andrea Tanzer; Bertram Vogel; Stefanie Wehner; Michael T. Wolfinger; Rolf Backofen; Jan Gorodkin; Ivo Grosse; Ivo Hofacker; Steve Hoffmann; Christoph Kaleta; Peter F. Stadler; Stephan Becker; Manja Marz

doi:10.1038/srep34589

Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells: [Plus] Corrigendum

Martin Hölzer, Verena Krähling, Fabian Amman, Emanuel Barth, Stephan H. Bernhart, Victor Adriano Okstoft Carmelo, Maximilian Collatz, Gero Doose, Florian Eggenhofer, Jan Ewald, Jörg Fallmann, Lasse M. Feldhahn, Markus Fricke, Juliane Gebauer, Andreas J. Gruber, Franziska Hufsky, Henrike Indrischek, Sabina Kanton, Jörg Linde, Nelly MostajoRoman Ochsenreiter, Konstantin Riege, Lorena Rivarola-Duarte, Abdullah H. Sahyoun, Sita J. Saunders, Ernst Stefan Seemann, Andrea Tanzer, Bertram Vogel, Stefanie Wehner, Michael T. Wolfinger, Rolf Backofen, Jan Gorodkin, Ivo Grosse, Ivo Hofacker, Steve Hoffmann, Christoph Kaleta, Peter F. Stadler, Stephan Becker, Manja Marz

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Abstract

The unprecedented outbreak of Ebola in West Africa resulted in over 28,000 cases and 11,000 deaths, underlining the need for a better understanding of the biology of this highly pathogenic virus to develop specific counter strategies. Two filoviruses, the Ebola and Marburg viruses, result in a severe and often fatal infection in humans. However, bats are natural hosts and survive filovirus infections without obvious symptoms. The molecular basis of this striking difference in the response to filovirus infections is not well understood. We report a systematic overview of differentially expressed genes, activity motifs and pathways in human and bat cells infected with the Ebola and Marburg viruses, and we demonstrate that the replication of filoviruses is more rapid in human cells than in bat cells. We also found that the most strongly regulated genes upon filovirus infection are chemokine ligands and transcription factors. We observed a strong induction of the JAK/STAT pathway, of several genes encoding inhibitors of MAP kinases (DUSP genes) and of PPP1R15A, which is involved in ER stress-induced cell death. We used comparative transcriptomics to provide a data resource that can be used to identify cellular responses that might allow bats to survive filovirus infections.

Original language	English
Article number	34589
Journal	Scientific Reports
Volume	6
Number of pages	16
ISSN	2045-2322
DOIs	https://doi.org/10.1038/srep34589
Publication status	Published - 7 Oct 2016

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Hölzer, M., Krähling, V., Amman, F., Barth, E., Bernhart, S. H., Carmelo, V. A. O., Collatz, M., Doose, G., Eggenhofer, F., Ewald, J., Fallmann, J., Feldhahn, L. M., Fricke, M., Gebauer, J., Gruber, A. J., Hufsky, F., Indrischek, H., Kanton, S., Linde, J., ... Marz, M. (2016). Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells: [Plus] Corrigendum. Scientific Reports, 6, Article 34589. https://doi.org/10.1038/srep34589

Hölzer, M, Krähling, V, Amman, F, Barth, E, Bernhart, SH, Carmelo, VAO, Collatz, M, Doose, G, Eggenhofer, F, Ewald, J, Fallmann, J, Feldhahn, LM, Fricke, M, Gebauer, J, Gruber, AJ, Hufsky, F, Indrischek, H, Kanton, S, Linde, J, Mostajo, N, Ochsenreiter, R, Riege, K, Rivarola-Duarte, L, Sahyoun, AH, Saunders, SJ, Seemann, ES, Tanzer, A, Vogel, B, Wehner, S, Wolfinger, MT, Backofen, R, Gorodkin, J, Grosse, I, Hofacker, I, Hoffmann, S, Kaleta, C, Stadler, PF, Becker, S & Marz, M 2016, 'Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells: [Plus] Corrigendum', Scientific Reports, vol. 6, 34589. https://doi.org/10.1038/srep34589

@article{04b1a64f194b48f7a67c80e708cdf2ae,

title = "Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells: [Plus] Corrigendum",

abstract = "The unprecedented outbreak of Ebola in West Africa resulted in over 28,000 cases and 11,000 deaths, underlining the need for a better understanding of the biology of this highly pathogenic virus to develop specific counter strategies. Two filoviruses, the Ebola and Marburg viruses, result in a severe and often fatal infection in humans. However, bats are natural hosts and survive filovirus infections without obvious symptoms. The molecular basis of this striking difference in the response to filovirus infections is not well understood. We report a systematic overview of differentially expressed genes, activity motifs and pathways in human and bat cells infected with the Ebola and Marburg viruses, and we demonstrate that the replication of filoviruses is more rapid in human cells than in bat cells. We also found that the most strongly regulated genes upon filovirus infection are chemokine ligands and transcription factors. We observed a strong induction of the JAK/STAT pathway, of several genes encoding inhibitors of MAP kinases (DUSP genes) and of PPP1R15A, which is involved in ER stress-induced cell death. We used comparative transcriptomics to provide a data resource that can be used to identify cellular responses that might allow bats to survive filovirus infections.",

author = "Martin H{\"o}lzer and Verena Kr{\"a}hling and Fabian Amman and Emanuel Barth and Bernhart, {Stephan H.} and Carmelo, {Victor Adriano Okstoft} and Maximilian Collatz and Gero Doose and Florian Eggenhofer and Jan Ewald and J{\"o}rg Fallmann and Feldhahn, {Lasse M.} and Markus Fricke and Juliane Gebauer and Gruber, {Andreas J.} and Franziska Hufsky and Henrike Indrischek and Sabina Kanton and J{\"o}rg Linde and Nelly Mostajo and Roman Ochsenreiter and Konstantin Riege and Lorena Rivarola-Duarte and Sahyoun, {Abdullah H.} and Saunders, {Sita J.} and Seemann, {Ernst Stefan} and Andrea Tanzer and Bertram Vogel and Stefanie Wehner and Wolfinger, {Michael T.} and Rolf Backofen and Jan Gorodkin and Ivo Grosse and Ivo Hofacker and Steve Hoffmann and Christoph Kaleta and Stadler, {Peter F.} and Stephan Becker and Manja Marz",

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doi = "10.1038/srep34589",

language = "English",

volume = "6",

journal = "Scientific Reports",

issn = "2045-2322",

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T1 - Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells

T2 - [Plus] Corrigendum

AU - Hölzer, Martin

AU - Krähling, Verena

AU - Amman, Fabian

AU - Barth, Emanuel

AU - Bernhart, Stephan H.

AU - Carmelo, Victor Adriano Okstoft

AU - Collatz, Maximilian

AU - Doose, Gero

AU - Eggenhofer, Florian

AU - Ewald, Jan

AU - Fallmann, Jörg

AU - Feldhahn, Lasse M.

AU - Fricke, Markus

AU - Gebauer, Juliane

AU - Gruber, Andreas J.

AU - Hufsky, Franziska

AU - Indrischek, Henrike

AU - Kanton, Sabina

AU - Linde, Jörg

AU - Mostajo, Nelly

AU - Ochsenreiter, Roman

AU - Riege, Konstantin

AU - Rivarola-Duarte, Lorena

AU - Sahyoun, Abdullah H.

AU - Saunders, Sita J.

AU - Seemann, Ernst Stefan

AU - Tanzer, Andrea

AU - Vogel, Bertram

AU - Wehner, Stefanie

AU - Wolfinger, Michael T.

AU - Backofen, Rolf

AU - Gorodkin, Jan

AU - Grosse, Ivo

AU - Hofacker, Ivo

AU - Hoffmann, Steve

AU - Kaleta, Christoph

AU - Stadler, Peter F.

AU - Becker, Stephan

AU - Marz, Manja

PY - 2016/10/7

Y1 - 2016/10/7

N2 - The unprecedented outbreak of Ebola in West Africa resulted in over 28,000 cases and 11,000 deaths, underlining the need for a better understanding of the biology of this highly pathogenic virus to develop specific counter strategies. Two filoviruses, the Ebola and Marburg viruses, result in a severe and often fatal infection in humans. However, bats are natural hosts and survive filovirus infections without obvious symptoms. The molecular basis of this striking difference in the response to filovirus infections is not well understood. We report a systematic overview of differentially expressed genes, activity motifs and pathways in human and bat cells infected with the Ebola and Marburg viruses, and we demonstrate that the replication of filoviruses is more rapid in human cells than in bat cells. We also found that the most strongly regulated genes upon filovirus infection are chemokine ligands and transcription factors. We observed a strong induction of the JAK/STAT pathway, of several genes encoding inhibitors of MAP kinases (DUSP genes) and of PPP1R15A, which is involved in ER stress-induced cell death. We used comparative transcriptomics to provide a data resource that can be used to identify cellular responses that might allow bats to survive filovirus infections.

AB - The unprecedented outbreak of Ebola in West Africa resulted in over 28,000 cases and 11,000 deaths, underlining the need for a better understanding of the biology of this highly pathogenic virus to develop specific counter strategies. Two filoviruses, the Ebola and Marburg viruses, result in a severe and often fatal infection in humans. However, bats are natural hosts and survive filovirus infections without obvious symptoms. The molecular basis of this striking difference in the response to filovirus infections is not well understood. We report a systematic overview of differentially expressed genes, activity motifs and pathways in human and bat cells infected with the Ebola and Marburg viruses, and we demonstrate that the replication of filoviruses is more rapid in human cells than in bat cells. We also found that the most strongly regulated genes upon filovirus infection are chemokine ligands and transcription factors. We observed a strong induction of the JAK/STAT pathway, of several genes encoding inhibitors of MAP kinases (DUSP genes) and of PPP1R15A, which is involved in ER stress-induced cell death. We used comparative transcriptomics to provide a data resource that can be used to identify cellular responses that might allow bats to survive filovirus infections.

UR - http://10.1038/srep39421

U2 - 10.1038/srep34589

DO - 10.1038/srep34589

M3 - Journal article

C2 - 27713552

SN - 2045-2322

VL - 6

JO - Scientific Reports

JF - Scientific Reports

M1 - 34589

ER -

Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells: [Plus] Corrigendum

Abstract

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