Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum

D R Cavanagh; C Dobaño; I M Elhassan; K Marsh; A Elhassan; L Hviid; E A Khalil; T G Theander; D E Arnot; J S McBride

doi:10.1128/IAI.69.2.1207-1211.2001

Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum

D R Cavanagh, C Dobaño, I M Elhassan, K Marsh, A Elhassan, L Hviid, E A Khalil, T G Theander, D E Arnot, J S McBride

58 Citations (Scopus)

Abstract

Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.

Original language	English
Journal	Infection and Immunity
Volume	69
Issue number	2
Pages (from-to)	1207-11
Number of pages	4
ISSN	0019-9567
DOIs	https://doi.org/10.1128/IAI.69.2.1207-1211.2001
Publication status	Published - 2001

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1128/IAI.69.2.1207-1211.2001

Cite this

Cavanagh, D. R., Dobaño, C., Elhassan, I. M., Marsh, K., Elhassan, A., Hviid, L., Khalil, E. A., Theander, T. G., Arnot, D. E., & McBride, J. S. (2001). Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum. Infection and Immunity, 69(2), 1207-11. https://doi.org/10.1128/IAI.69.2.1207-1211.2001

Cavanagh, DR, Dobaño, C, Elhassan, IM, Marsh, K, Elhassan, A, Hviid, L, Khalil, EA, Theander, TG, Arnot, DE & McBride, JS 2001, 'Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum', Infection and Immunity, vol. 69, no. 2, pp. 1207-11. https://doi.org/10.1128/IAI.69.2.1207-1211.2001

@article{b1147c40a03a11dd86a6000ea68e967b,

title = "Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum",

abstract = "Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.",

author = "Cavanagh, {D R} and C Doba{\~n}o and Elhassan, {I M} and K Marsh and A Elhassan and L Hviid and Khalil, {E A} and Theander, {T G} and Arnot, {D E} and McBride, {J S}",

note = "Keywords: Adolescent; Adult; Aged; Animals; Antibodies, Protozoan; Child; Child, Preschool; Humans; Immunoglobulin G; Infant; Merozoite Surface Protein 1; Middle Aged; Peptide Fragments; Plasmodium falciparum",

year = "2001",

doi = "10.1128/IAI.69.2.1207-1211.2001",

language = "English",

volume = "69",

pages = "1207--11",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "2",

}

TY - JOUR

T1 - Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum

AU - Cavanagh, D R

AU - Dobaño, C

AU - Elhassan, I M

AU - Marsh, K

AU - Elhassan, A

AU - Hviid, L

AU - Khalil, E A

AU - Theander, T G

AU - Arnot, D E

AU - McBride, J S

N1 - Keywords: Adolescent; Adult; Aged; Animals; Antibodies, Protozoan; Child; Child, Preschool; Humans; Immunoglobulin G; Infant; Merozoite Surface Protein 1; Middle Aged; Peptide Fragments; Plasmodium falciparum

PY - 2001

Y1 - 2001

N2 - Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.

AB - Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.

U2 - 10.1128/IAI.69.2.1207-1211.2001

DO - 10.1128/IAI.69.2.1207-1211.2001

M3 - Journal article

C2 - 11160024

SN - 0019-9567

VL - 69

SP - 1207

EP - 1211

JO - Infection and Immunity

JF - Infection and Immunity

IS - 2

ER -

Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this