Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum

TY - JOUR

T1 - Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum

AU - Cavanagh, D R

AU - Dobaño, C

AU - Elhassan, I M

AU - Marsh, K

AU - Elhassan, A

AU - Hviid, L

AU - Khalil, E A

AU - Theander, T G

AU - Arnot, D E

AU - McBride, J S

N1 - Keywords: Adolescent; Adult; Aged; Animals; Antibodies, Protozoan; Child; Child, Preschool; Humans; Immunoglobulin G; Infant; Merozoite Surface Protein 1; Middle Aged; Peptide Fragments; Plasmodium falciparum

PY - 2001

Y1 - 2001

N2 - Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.

AB - Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.

U2 - 10.1128/IAI.69.2.1207-1211.2001

DO - 10.1128/IAI.69.2.1207-1211.2001

M3 - Journal article

C2 - 11160024

SN - 0019-9567

VL - 69

SP - 1207

EP - 1211

JO - Infection and Immunity

JF - Infection and Immunity

IS - 2

ER -