Diet-microbiota interactions as moderators of human metabolism

Justin L Sonnenburg; Gert Fredrik Bäckhed

doi:10.1038/nature18846

Diet-microbiota interactions as moderators of human metabolism

Justin L Sonnenburg, Gert Fredrik Bäckhed

789 Citations (Scopus)

Abstract

It is widely accepted that obesity and associated metabolic diseases, including type 2 diabetes, are intimately linked to diet. However, the gut microbiota has also become a focus for research at the intersection of diet and metabolic health. Mechanisms that link the gut microbiota with obesity are coming to light through a powerful combination of translation-focused animal models and studies in humans. A body of knowledge is accumulating that points to the gut microbiota as a mediator of dietary impact on the host metabolic status. Efforts are focusing on the establishment of causal relationships in people and the prospect of therapeutic interventions such as personalized nutrition.

Original language	English
Journal	Nature
Volume	535
Issue number	7610
Pages (from-to)	56-64
Number of pages	9
ISSN	0028-0836
DOIs	https://doi.org/10.1038/nature18846
Publication status	Published - 6 Jul 2016

Keywords

Animals
Diabetes Mellitus, Type 2
Diet
Fatty Acids
Gastrointestinal Microbiome
Humans
Inflammation
Metabolic Diseases
Metabolism
Obesity
Precision Medicine
Signal Transduction
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nature18846

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abstract = "It is widely accepted that obesity and associated metabolic diseases, including type 2 diabetes, are intimately linked to diet. However, the gut microbiota has also become a focus for research at the intersection of diet and metabolic health. Mechanisms that link the gut microbiota with obesity are coming to light through a powerful combination of translation-focused animal models and studies in humans. A body of knowledge is accumulating that points to the gut microbiota as a mediator of dietary impact on the host metabolic status. Efforts are focusing on the establishment of causal relationships in people and the prospect of therapeutic interventions such as personalized nutrition.",

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AU - Bäckhed, Gert Fredrik

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KW - Diabetes Mellitus, Type 2

KW - Diet

KW - Fatty Acids

KW - Gastrointestinal Microbiome

KW - Humans

KW - Inflammation

KW - Metabolic Diseases

KW - Metabolism

KW - Obesity

KW - Precision Medicine

KW - Signal Transduction

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

KW - Review

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DO - 10.1038/nature18846

M3 - Review

C2 - 27383980

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VL - 535

SP - 56

EP - 64

JO - Nature

JF - Nature

IS - 7610

ER -

Diet-microbiota interactions as moderators of human metabolism

Abstract

Keywords

UN SDGs

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