Diet-microbiota interactions as moderators of human metabolism

Justin L Sonnenburg; Gert Fredrik Bäckhed

doi:10.1038/nature18846

Diet-microbiota interactions as moderators of human metabolism

Justin L Sonnenburg, Gert Fredrik Bäckhed

789 Citationer (Scopus)

Abstract

It is widely accepted that obesity and associated metabolic diseases, including type 2 diabetes, are intimately linked to diet. However, the gut microbiota has also become a focus for research at the intersection of diet and metabolic health. Mechanisms that link the gut microbiota with obesity are coming to light through a powerful combination of translation-focused animal models and studies in humans. A body of knowledge is accumulating that points to the gut microbiota as a mediator of dietary impact on the host metabolic status. Efforts are focusing on the establishment of causal relationships in people and the prospect of therapeutic interventions such as personalized nutrition.

Originalsprog	Engelsk
Tidsskrift	Nature
Vol/bind	535
Udgave nummer	7610
Sider (fra-til)	56-64
Antal sider	9
ISSN	0028-0836
DOI	https://doi.org/10.1038/nature18846
Status	Udgivet - 6 jul. 2016

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10.1038/nature18846

Citationsformater

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keywords = "Animals, Diabetes Mellitus, Type 2, Diet, Fatty Acids, Gastrointestinal Microbiome, Humans, Inflammation, Metabolic Diseases, Metabolism, Obesity, Precision Medicine, Signal Transduction, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review",

author = "Sonnenburg, {Justin L} and B{\"a}ckhed, {Gert Fredrik}",

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AU - Bäckhed, Gert Fredrik

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N2 - It is widely accepted that obesity and associated metabolic diseases, including type 2 diabetes, are intimately linked to diet. However, the gut microbiota has also become a focus for research at the intersection of diet and metabolic health. Mechanisms that link the gut microbiota with obesity are coming to light through a powerful combination of translation-focused animal models and studies in humans. A body of knowledge is accumulating that points to the gut microbiota as a mediator of dietary impact on the host metabolic status. Efforts are focusing on the establishment of causal relationships in people and the prospect of therapeutic interventions such as personalized nutrition.

AB - It is widely accepted that obesity and associated metabolic diseases, including type 2 diabetes, are intimately linked to diet. However, the gut microbiota has also become a focus for research at the intersection of diet and metabolic health. Mechanisms that link the gut microbiota with obesity are coming to light through a powerful combination of translation-focused animal models and studies in humans. A body of knowledge is accumulating that points to the gut microbiota as a mediator of dietary impact on the host metabolic status. Efforts are focusing on the establishment of causal relationships in people and the prospect of therapeutic interventions such as personalized nutrition.

KW - Animals

KW - Diabetes Mellitus, Type 2

KW - Diet

KW - Fatty Acids

KW - Gastrointestinal Microbiome

KW - Humans

KW - Inflammation

KW - Metabolic Diseases

KW - Metabolism

KW - Obesity

KW - Precision Medicine

KW - Signal Transduction

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1038/nature18846

DO - 10.1038/nature18846

M3 - Review

C2 - 27383980

SN - 0028-0836

VL - 535

SP - 56

EP - 64

JO - Nature

JF - Nature

IS - 7610

ER -

Diet-microbiota interactions as moderators of human metabolism

Abstract

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