Diatom isoprenoids: Advances and biotechnological potential

Anastasia Athanasakoglou; Sotirios C. Kampranis

doi:10.1016/j.biotechadv.2019.107417

Diatom isoprenoids: Advances and biotechnological potential

Anastasia Athanasakoglou, Sotirios C. Kampranis^*

^*Corresponding author for this work

Section for Plant Biochemistry

7 Citations (Scopus)

Abstract

Diatoms are among the most productive and ecologically important groups of microalgae in contemporary oceans. Due to their distinctive metabolic and physiological features, they offer exciting opportunities for a broad range of commercial and industrial applications. One such feature is their ability to synthesize a wide diversity of isoprenoid compounds. However, limited understanding of how these molecules are synthesized have until recently hindered their exploitation. Following comprehensive genomic and transcriptomic analysis of various diatom species, the biosynthetic mechanisms and regulation of the different branches of the pathway are now beginning to be elucidated. In this review, we provide a summary of the recent advances in understanding diatom isoprenoid synthesis and discuss the exploitation potential of diatoms as chassis for high-value isoprenoid synthesis.

Original language	English
Article number	107417
Journal	Biotechnology Advances
Volume	37
Issue number	8
ISSN	0734-9750
DOIs	https://doi.org/10.1016/j.biotechadv.2019.107417
Publication status	Published - Dec 2019

Keywords

Carotenoid
High-value compounds
Isoprenoid
Microalgae
Specialized metabolism
Sterol
Terpenoid

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10.1016/j.biotechadv.2019.107417

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abstract = "Diatoms are among the most productive and ecologically important groups of microalgae in contemporary oceans. Due to their distinctive metabolic and physiological features, they offer exciting opportunities for a broad range of commercial and industrial applications. One such feature is their ability to synthesize a wide diversity of isoprenoid compounds. However, limited understanding of how these molecules are synthesized have until recently hindered their exploitation. Following comprehensive genomic and transcriptomic analysis of various diatom species, the biosynthetic mechanisms and regulation of the different branches of the pathway are now beginning to be elucidated. In this review, we provide a summary of the recent advances in understanding diatom isoprenoid synthesis and discuss the exploitation potential of diatoms as chassis for high-value isoprenoid synthesis.",

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Diatom isoprenoids: Advances and biotechnological potential

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Keywords

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