TY - JOUR
T1 - Diatom isoprenoids
T2 - Advances and biotechnological potential
AU - Athanasakoglou, Anastasia
AU - Kampranis, Sotirios C.
PY - 2019/12
Y1 - 2019/12
N2 - Diatoms are among the most productive and ecologically important groups of microalgae in contemporary oceans. Due to their distinctive metabolic and physiological features, they offer exciting opportunities for a broad range of commercial and industrial applications. One such feature is their ability to synthesize a wide diversity of isoprenoid compounds. However, limited understanding of how these molecules are synthesized have until recently hindered their exploitation. Following comprehensive genomic and transcriptomic analysis of various diatom species, the biosynthetic mechanisms and regulation of the different branches of the pathway are now beginning to be elucidated. In this review, we provide a summary of the recent advances in understanding diatom isoprenoid synthesis and discuss the exploitation potential of diatoms as chassis for high-value isoprenoid synthesis.
AB - Diatoms are among the most productive and ecologically important groups of microalgae in contemporary oceans. Due to their distinctive metabolic and physiological features, they offer exciting opportunities for a broad range of commercial and industrial applications. One such feature is their ability to synthesize a wide diversity of isoprenoid compounds. However, limited understanding of how these molecules are synthesized have until recently hindered their exploitation. Following comprehensive genomic and transcriptomic analysis of various diatom species, the biosynthetic mechanisms and regulation of the different branches of the pathway are now beginning to be elucidated. In this review, we provide a summary of the recent advances in understanding diatom isoprenoid synthesis and discuss the exploitation potential of diatoms as chassis for high-value isoprenoid synthesis.
KW - Carotenoid
KW - High-value compounds
KW - Isoprenoid
KW - Microalgae
KW - Specialized metabolism
KW - Sterol
KW - Terpenoid
UR - http://www.scopus.com/inward/record.url?scp=85071301600&partnerID=8YFLogxK
U2 - 10.1016/j.biotechadv.2019.107417
DO - 10.1016/j.biotechadv.2019.107417
M3 - Review
C2 - 31326522
AN - SCOPUS:85071301600
SN - 0734-9750
VL - 37
JO - Biotechnology Advances
JF - Biotechnology Advances
IS - 8
M1 - 107417
ER -