Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex.

Keyphrases

• Diarylurea 100%
• Inhibitor of Apoptosis Proteins 66%
• Tetrapeptide 16%
• Complex Activation 16%
• Endogenous Apoptosis 16%
• Specific Tools 16%
• Mitochondria-dependent 16%
• Protein Antagonist 16%
• Initiator Caspase 16%
• Apoptotic Pathway 16%
• Smac 16%
• HtrA2 16%
• DIABLO 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Apoptosome 100%
• Inhibitor of Apoptosis Protein 42%
• Cytochrome C 42%
• Apoptosis Inhibitor 14%
• Caspase 9 14%
• Tetrapeptide 14%
• Initiator Caspase 14%