Diagnostic challenges in clinical, radiological and histopathological tests regarding papillomatous lesions of the breast

Birgitte Bruun Rasmussen; Eva Balslev; Ib Jarle Christensen; Charlotte Lanng; Anne Bak; Hanne Galatius; Maj-Lis Møller Talman; Nahid Sharghi Someh; Ilse Vejborg; Mette Okholm

doi:10.1016/j.breast.2018.05.006

Diagnostic challenges in clinical, radiological and histopathological tests regarding papillomatous lesions of the breast

Birgitte Bruun Rasmussen, Eva Balslev, Ib Jarle Christensen, Charlotte Lanng, Anne Bak, Hanne Galatius, Maj-Lis Møller Talman, Nahid Sharghi Someh, Ilse Vejborg, Mette Okholm

Department of Clinical Medicine

3 Citations (Scopus)

Abstract

Papillomas of the female breast is a relatively frequent lesion, and the majority are benign when excised. However, some may host malignant or premalignant areas. Consequently, it is a worldwide accepted principle to excise the lesion whenever diagnosed. However, this leads to a large number of patients having an unnecessary operation. The present study was designed to investigate whether we could find clinical, radiological and pathological factors in the preoperative, diagnostic setting that could identify patients hosting a benign papilloma in order to avoid operation. The patient material consisted of 260 patients, all with a preoperative diagnosis of a papillomatous process in core biopsy. The lesion was excised, and 71% had a benign lesion. The rest had lesions ranging from premalignant to malignant. In the clinical, radiological and histopathological investigations conducted, we were not able to identify factors that statistically significant could predict whether the lesion was benign or malignant. However, our data showed a higher prevalence of malignant and premalignant lesions for older patient, larger lesions, and lesions found at a longer distance from the papilla. We conclude that, since almost 30% of the patients in our study ended up with a premalignant or malignant diagnosis, where no statistically significant preoperative factors could indicate a benign outcome, operation is warranted in all patients with a preoperative diagnosis of a papillomatous lesion.

Original language	English
Journal	Breast (Edinburgh, Scotland)
Volume	40
Pages (from-to)	177-180
Number of pages	4
ISSN	0960-9776
DOIs	https://doi.org/10.1016/j.breast.2018.05.006
Publication status	Published - Aug 2018

Keywords

Adult
Age Factors
Aged
Biopsy, Large-Core Needle/statistics & numerical data
Breast/diagnostic imaging
Breast Neoplasms/diagnosis
Denmark
Early Detection of Cancer/statistics & numerical data
Female
Humans
Mammography/statistics & numerical data
Middle Aged
Papilloma/diagnosis
Registries
Risk Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.breast.2018.05.006

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Rasmussen, B. B., Balslev, E., Jarle Christensen, I., Lanng, C., Bak, A., Galatius, H., Møller Talman, M-L., Sharghi Someh, N., Vejborg, I., & Okholm, M. (2018). Diagnostic challenges in clinical, radiological and histopathological tests regarding papillomatous lesions of the breast. Breast (Edinburgh, Scotland), 40, 177-180. https://doi.org/10.1016/j.breast.2018.05.006

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title = "Diagnostic challenges in clinical, radiological and histopathological tests regarding papillomatous lesions of the breast",

abstract = "Papillomas of the female breast is a relatively frequent lesion, and the majority are benign when excised. However, some may host malignant or premalignant areas. Consequently, it is a worldwide accepted principle to excise the lesion whenever diagnosed. However, this leads to a large number of patients having an unnecessary operation. The present study was designed to investigate whether we could find clinical, radiological and pathological factors in the preoperative, diagnostic setting that could identify patients hosting a benign papilloma in order to avoid operation. The patient material consisted of 260 patients, all with a preoperative diagnosis of a papillomatous process in core biopsy. The lesion was excised, and 71% had a benign lesion. The rest had lesions ranging from premalignant to malignant. In the clinical, radiological and histopathological investigations conducted, we were not able to identify factors that statistically significant could predict whether the lesion was benign or malignant. However, our data showed a higher prevalence of malignant and premalignant lesions for older patient, larger lesions, and lesions found at a longer distance from the papilla. We conclude that, since almost 30% of the patients in our study ended up with a premalignant or malignant diagnosis, where no statistically significant preoperative factors could indicate a benign outcome, operation is warranted in all patients with a preoperative diagnosis of a papillomatous lesion.",

keywords = "Adult, Age Factors, Aged, Biopsy, Large-Core Needle/statistics & numerical data, Breast/diagnostic imaging, Breast Neoplasms/diagnosis, Denmark, Early Detection of Cancer/statistics & numerical data, Female, Humans, Mammography/statistics & numerical data, Middle Aged, Papilloma/diagnosis, Registries, Risk Factors",

author = "Rasmussen, {Birgitte Bruun} and Eva Balslev and {Jarle Christensen}, Ib and Charlotte Lanng and Anne Bak and Hanne Galatius and {M{\o}ller Talman}, Maj-Lis and {Sharghi Someh}, Nahid and Ilse Vejborg and Mette Okholm",

year = "2018",

month = aug,

doi = "10.1016/j.breast.2018.05.006",

language = "English",

volume = "40",

pages = "177--180",

journal = "Breast",

issn = "0960-9776",

publisher = "Churchill Livingstone",

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TY - JOUR

T1 - Diagnostic challenges in clinical, radiological and histopathological tests regarding papillomatous lesions of the breast

AU - Rasmussen, Birgitte Bruun

AU - Balslev, Eva

AU - Jarle Christensen, Ib

AU - Lanng, Charlotte

AU - Bak, Anne

AU - Galatius, Hanne

AU - Møller Talman, Maj-Lis

AU - Sharghi Someh, Nahid

AU - Vejborg, Ilse

AU - Okholm, Mette

PY - 2018/8

Y1 - 2018/8

N2 - Papillomas of the female breast is a relatively frequent lesion, and the majority are benign when excised. However, some may host malignant or premalignant areas. Consequently, it is a worldwide accepted principle to excise the lesion whenever diagnosed. However, this leads to a large number of patients having an unnecessary operation. The present study was designed to investigate whether we could find clinical, radiological and pathological factors in the preoperative, diagnostic setting that could identify patients hosting a benign papilloma in order to avoid operation. The patient material consisted of 260 patients, all with a preoperative diagnosis of a papillomatous process in core biopsy. The lesion was excised, and 71% had a benign lesion. The rest had lesions ranging from premalignant to malignant. In the clinical, radiological and histopathological investigations conducted, we were not able to identify factors that statistically significant could predict whether the lesion was benign or malignant. However, our data showed a higher prevalence of malignant and premalignant lesions for older patient, larger lesions, and lesions found at a longer distance from the papilla. We conclude that, since almost 30% of the patients in our study ended up with a premalignant or malignant diagnosis, where no statistically significant preoperative factors could indicate a benign outcome, operation is warranted in all patients with a preoperative diagnosis of a papillomatous lesion.

AB - Papillomas of the female breast is a relatively frequent lesion, and the majority are benign when excised. However, some may host malignant or premalignant areas. Consequently, it is a worldwide accepted principle to excise the lesion whenever diagnosed. However, this leads to a large number of patients having an unnecessary operation. The present study was designed to investigate whether we could find clinical, radiological and pathological factors in the preoperative, diagnostic setting that could identify patients hosting a benign papilloma in order to avoid operation. The patient material consisted of 260 patients, all with a preoperative diagnosis of a papillomatous process in core biopsy. The lesion was excised, and 71% had a benign lesion. The rest had lesions ranging from premalignant to malignant. In the clinical, radiological and histopathological investigations conducted, we were not able to identify factors that statistically significant could predict whether the lesion was benign or malignant. However, our data showed a higher prevalence of malignant and premalignant lesions for older patient, larger lesions, and lesions found at a longer distance from the papilla. We conclude that, since almost 30% of the patients in our study ended up with a premalignant or malignant diagnosis, where no statistically significant preoperative factors could indicate a benign outcome, operation is warranted in all patients with a preoperative diagnosis of a papillomatous lesion.

KW - Adult

KW - Age Factors

KW - Aged

KW - Biopsy, Large-Core Needle/statistics & numerical data

KW - Breast/diagnostic imaging

KW - Breast Neoplasms/diagnosis

KW - Denmark

KW - Early Detection of Cancer/statistics & numerical data

KW - Female

KW - Humans

KW - Mammography/statistics & numerical data

KW - Middle Aged

KW - Papilloma/diagnosis

KW - Registries

KW - Risk Factors

U2 - 10.1016/j.breast.2018.05.006

DO - 10.1016/j.breast.2018.05.006

M3 - Journal article

C2 - 29906740

SN - 0960-9776

VL - 40

SP - 177

EP - 180

JO - Breast

JF - Breast

ER -

Diagnostic challenges in clinical, radiological and histopathological tests regarding papillomatous lesions of the breast

Abstract

Keywords

UN SDGs

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