TY - JOUR
T1 - Diagnostic challenges in clinical, radiological and histopathological tests regarding papillomatous lesions of the breast
AU - Rasmussen, Birgitte Bruun
AU - Balslev, Eva
AU - Jarle Christensen, Ib
AU - Lanng, Charlotte
AU - Bak, Anne
AU - Galatius, Hanne
AU - Møller Talman, Maj-Lis
AU - Sharghi Someh, Nahid
AU - Vejborg, Ilse
AU - Okholm, Mette
N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.
PY - 2018/8
Y1 - 2018/8
N2 - Papillomas of the female breast is a relatively frequent lesion, and the majority are benign when excised. However, some may host malignant or premalignant areas. Consequently, it is a worldwide accepted principle to excise the lesion whenever diagnosed. However, this leads to a large number of patients having an unnecessary operation. The present study was designed to investigate whether we could find clinical, radiological and pathological factors in the preoperative, diagnostic setting that could identify patients hosting a benign papilloma in order to avoid operation. The patient material consisted of 260 patients, all with a preoperative diagnosis of a papillomatous process in core biopsy. The lesion was excised, and 71% had a benign lesion. The rest had lesions ranging from premalignant to malignant. In the clinical, radiological and histopathological investigations conducted, we were not able to identify factors that statistically significant could predict whether the lesion was benign or malignant. However, our data showed a higher prevalence of malignant and premalignant lesions for older patient, larger lesions, and lesions found at a longer distance from the papilla. We conclude that, since almost 30% of the patients in our study ended up with a premalignant or malignant diagnosis, where no statistically significant preoperative factors could indicate a benign outcome, operation is warranted in all patients with a preoperative diagnosis of a papillomatous lesion.
AB - Papillomas of the female breast is a relatively frequent lesion, and the majority are benign when excised. However, some may host malignant or premalignant areas. Consequently, it is a worldwide accepted principle to excise the lesion whenever diagnosed. However, this leads to a large number of patients having an unnecessary operation. The present study was designed to investigate whether we could find clinical, radiological and pathological factors in the preoperative, diagnostic setting that could identify patients hosting a benign papilloma in order to avoid operation. The patient material consisted of 260 patients, all with a preoperative diagnosis of a papillomatous process in core biopsy. The lesion was excised, and 71% had a benign lesion. The rest had lesions ranging from premalignant to malignant. In the clinical, radiological and histopathological investigations conducted, we were not able to identify factors that statistically significant could predict whether the lesion was benign or malignant. However, our data showed a higher prevalence of malignant and premalignant lesions for older patient, larger lesions, and lesions found at a longer distance from the papilla. We conclude that, since almost 30% of the patients in our study ended up with a premalignant or malignant diagnosis, where no statistically significant preoperative factors could indicate a benign outcome, operation is warranted in all patients with a preoperative diagnosis of a papillomatous lesion.
KW - Adult
KW - Age Factors
KW - Aged
KW - Biopsy, Large-Core Needle/statistics & numerical data
KW - Breast/diagnostic imaging
KW - Breast Neoplasms/diagnosis
KW - Denmark
KW - Early Detection of Cancer/statistics & numerical data
KW - Female
KW - Humans
KW - Mammography/statistics & numerical data
KW - Middle Aged
KW - Papilloma/diagnosis
KW - Registries
KW - Risk Factors
U2 - 10.1016/j.breast.2018.05.006
DO - 10.1016/j.breast.2018.05.006
M3 - Journal article
C2 - 29906740
SN - 0960-9776
VL - 40
SP - 177
EP - 180
JO - Breast
JF - Breast
ER -
