Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs

Tuomas O. Lilius, Kim Blomqvist, Natalie L. Hauglund, Guojun Liu, Frederik Filip Stæger, Simone Baerentzen, Ting Du, Fredrik Ahlstrom, Janne T. Backman, Eija A. Kalso, Pekka, V Rauhala, Maiken Nedergaard

    16 Citations (Scopus)
    34 Downloads (Pure)
    Original languageEnglish
    JournalJournal of Controlled Release
    Volume304
    Pages (from-to)29-38
    Number of pages10
    ISSN0168-3659
    DOIs
    Publication statusPublished - 28 Jun 2019

    Keywords

    • Drug delivery
    • Glymphatic system
    • Pharmacokinetics
    • alpha(2)-adrenergic agonist
    • Dexmedetomidine
    • Opioid
    • Amyloid-beta
    • Antibody therapy

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