Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs

Tuomas O. Lilius; Kim Blomqvist; Natalie L. Hauglund; Guojun Liu; Frederik Filip Stæger; Simone Baerentzen; Ting Du; Fredrik Ahlstrom; Janne T. Backman; Eija A. Kalso; Pekka, V Rauhala; Maiken Nedergaard

doi:10.1016/j.jconrel.2019.05.005

Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs

Tuomas O. Lilius, Kim Blomqvist, Natalie L. Hauglund, Guojun Liu, Frederik Filip Stæger, Simone Baerentzen, Ting Du, Fredrik Ahlstrom, Janne T. Backman, Eija A. Kalso, Pekka, V Rauhala, Maiken Nedergaard

16 Citationer (Scopus)

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Originalsprog	Engelsk
Tidsskrift	Journal of Controlled Release
Vol/bind	304
Sider (fra-til)	29-38
Antal sider	10
ISSN	0168-3659
DOI	https://doi.org/10.1016/j.jconrel.2019.05.005
Status	Udgivet - 28 jun. 2019

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10.1016/j.jconrel.2019.05.005Licens: CC BY-NC-ND

Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugsForlagets udgivne version, 2,96 MBLicens: CC BY-NC-ND

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@article{1112159432684df0913ea9fb0c992372,

title = "Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs",

keywords = "Drug delivery, Glymphatic system, Pharmacokinetics, alpha(2)-adrenergic agonist, Dexmedetomidine, Opioid, Amyloid-beta, Antibody therapy",

author = "Lilius, {Tuomas O.} and Kim Blomqvist and Hauglund, {Natalie L.} and Guojun Liu and St{\ae}ger, {Frederik Filip} and Simone Baerentzen and Ting Du and Fredrik Ahlstrom and Backman, {Janne T.} and Kalso, {Eija A.} and Rauhala, {Pekka, V} and Maiken Nedergaard",

year = "2019",

month = jun,

day = "28",

doi = "10.1016/j.jconrel.2019.05.005",

language = "English",

volume = "304",

pages = "29--38",

journal = "Journal of Controlled Release",

issn = "0168-3659",

publisher = "Elsevier",

}

TY - JOUR

T1 - Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs

AU - Lilius, Tuomas O.

AU - Blomqvist, Kim

AU - Hauglund, Natalie L.

AU - Liu, Guojun

AU - Stæger, Frederik Filip

AU - Baerentzen, Simone

AU - Du, Ting

AU - Ahlstrom, Fredrik

AU - Backman, Janne T.

AU - Kalso, Eija A.

AU - Rauhala, Pekka, V

AU - Nedergaard, Maiken

PY - 2019/6/28

Y1 - 2019/6/28

KW - Drug delivery

KW - Glymphatic system

KW - Pharmacokinetics

KW - alpha(2)-adrenergic agonist

KW - Dexmedetomidine

KW - Opioid

KW - Amyloid-beta

KW - Antibody therapy

U2 - 10.1016/j.jconrel.2019.05.005

DO - 10.1016/j.jconrel.2019.05.005

M3 - Journal article

C2 - 31067483

SN - 0168-3659

VL - 304

SP - 29

EP - 38

JO - Journal of Controlled Release

JF - Journal of Controlled Release

ER -

Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs

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