TY - JOUR
T1 - Development of a Fetal Weight Chart Using Serial Trans-Abdominal Ultrasound in an East African Population
T2 - A Longitudinal Observational Study
AU - Schmiegelow, Christentze
AU - Scheike, Thomas
AU - Oesterholt, Mayke
AU - Minja, Daniel
AU - Pehrson, Caroline
AU - Magistrado, Pamela
AU - Lemnge, Martha
AU - Rasch, Vibeke
AU - Lusingu, John
AU - Theander, Thor G.
AU - Nielsen, Birgitte Bruun
PY - 2012/9/21
Y1 - 2012/9/21
N2 - Objective: To produce a fetal weight chart representative of a Tanzanian population, and compare it to weight charts from Sub-Saharan Africa and the developed world. Methods: A longitudinal observational study in Northeastern Tanzania. Pregnant women were followed throughout pregnancy with serial trans-abdominal ultrasound. All pregnancies with pathology were excluded and a chart representing the optimal growth potential was developed using fetal weights and birth weights. The weight chart was compared to a chart from Congo, a chart representing a white population, and a chart representing a white population but adapted to the study population. The prevalence of SGA was assessed using all four charts. Results: A total of 2193 weight measurements from 583 fetuses/newborns were included in the fetal weight chart. Our chart had lower percentiles than all the other charts. Most importantly, in the end of pregnancy, the 10th percentiles deviated substantially causing an overestimation of the true prevalence of SGA newborns if our chart had not been used. Conclusions: We developed a weight chart representative for a Tanzanian population and provide evidence for the necessity of developing regional specific weight charts for correct identification of SGA. Our weight chart is an important tool that can be used for clinical risk assessments of newborns and for evaluating the effect of intrauterine exposures on fetal and newborn weight.
AB - Objective: To produce a fetal weight chart representative of a Tanzanian population, and compare it to weight charts from Sub-Saharan Africa and the developed world. Methods: A longitudinal observational study in Northeastern Tanzania. Pregnant women were followed throughout pregnancy with serial trans-abdominal ultrasound. All pregnancies with pathology were excluded and a chart representing the optimal growth potential was developed using fetal weights and birth weights. The weight chart was compared to a chart from Congo, a chart representing a white population, and a chart representing a white population but adapted to the study population. The prevalence of SGA was assessed using all four charts. Results: A total of 2193 weight measurements from 583 fetuses/newborns were included in the fetal weight chart. Our chart had lower percentiles than all the other charts. Most importantly, in the end of pregnancy, the 10th percentiles deviated substantially causing an overestimation of the true prevalence of SGA newborns if our chart had not been used. Conclusions: We developed a weight chart representative for a Tanzanian population and provide evidence for the necessity of developing regional specific weight charts for correct identification of SGA. Our weight chart is an important tool that can be used for clinical risk assessments of newborns and for evaluating the effect of intrauterine exposures on fetal and newborn weight.
UR - http://www.scopus.com/inward/record.url?scp=84866686634&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0044773
DO - 10.1371/journal.pone.0044773
M3 - Journal article
C2 - 23028617
AN - SCOPUS:84866686634
SN - 1932-6203
VL - 7
JO - PLoS Computational Biology
JF - PLoS Computational Biology
IS - 9
M1 - e44773
ER -