Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

Matthias Manfred Herth; Valdemar L.  Andersen; Szabolcs Lehel; Jacob Madsen; Gitte Moos Knudsen; Jesper Langgaard Kristensen

doi:10.1039/c3cc41027g

Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

Matthias Manfred Herth, Valdemar L. Andersen, Szabolcs Lehel, Jacob Madsen, Gitte Moos Knudsen, Jesper Langgaard Kristensen

LUKKET: Institut for Lægemiddeldesign og Farmakologi

49 Citationer (Scopus)

Abstract

Tetrazine–trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first 11C-labelled tetrazine and its reaction with trans-cyclooctenol.

Originalsprog	Engelsk
Tidsskrift	Chemical Communications
Vol/bind	49
Sider (fra-til)	3805-3807
Antal sider	3
ISSN	1359-7345
DOI	https://doi.org/10.1039/c3cc41027g
Status	Udgivet - 9 apr. 2013

Adgang til dokumentet

10.1039/c3cc41027g

Citationsformater

@article{9cc2b1053af8441d8370daf1ae9ae9a8,

title = "Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation",

abstract = "Tetrazine–trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first 11C-labelled tetrazine and its reaction with trans-cyclooctenol.",

author = "Herth, {Matthias Manfred} and Andersen, {Valdemar L.} and Szabolcs Lehel and Jacob Madsen and Knudsen, {Gitte Moos} and Kristensen, {Jesper Langgaard}",

year = "2013",

month = apr,

day = "9",

doi = "10.1039/c3cc41027g",

language = "English",

volume = "49",

pages = "3805--3807",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

}

TY - JOUR

T1 - Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

AU - Herth, Matthias Manfred

AU - Andersen, Valdemar L.

AU - Lehel, Szabolcs

AU - Madsen, Jacob

AU - Knudsen, Gitte Moos

AU - Kristensen, Jesper Langgaard

PY - 2013/4/9

Y1 - 2013/4/9

N2 - Tetrazine–trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first 11C-labelled tetrazine and its reaction with trans-cyclooctenol.

AB - Tetrazine–trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first 11C-labelled tetrazine and its reaction with trans-cyclooctenol.

U2 - 10.1039/c3cc41027g

DO - 10.1039/c3cc41027g

M3 - Journal article

SN - 1359-7345

VL - 49

SP - 3805

EP - 3807

JO - Chemical Communications

JF - Chemical Communications

ER -