Development and validation of the EUROFORGEN NAME (North African and Middle Eastern) ancestry panel

Vania Pereira; Ana Freire-Aradas; David Ballard; Claus Børsting; V. Diez; Paulina Pruszkowska-Przybylska; J. Ribeiro; Niaz M Achakzai; Anastasia Aliferi; Ozlem Bulbul; Maria D Perez-Carceles; Soumaya  Triki-Fendri; Ahmed Rebai; D Syndercombe-Court; Niels Morling; Maviky Lareu; Angel Carracedo; null The EUROFORGEN-NoE Consortium; Christoffer Phillips

doi:10.1016/j.fsigen.2019.06.010

Development and validation of the EUROFORGEN NAME (North African and Middle Eastern) ancestry panel

Vania Pereira, Ana Freire-Aradas, David Ballard, Claus Børsting, V. Diez, Paulina Pruszkowska-Przybylska, J. Ribeiro, Niaz M Achakzai, Anastasia Aliferi, Ozlem Bulbul, Maria D Perez-Carceles, Soumaya Triki-Fendri, Ahmed Rebai, D Syndercombe-Court, Niels Morling, Maviky Lareu, Angel Carracedo, The EUROFORGEN-NoE Consortium, Christoffer Phillips

Section of Forensic Genetics

11 Citations (Scopus)

Abstract

Inference of biogeographic origin is an important factor in clinical, population and forensic genetics. The information provided by AIMs (Ancestry Informative Markers) can allow the differentiation of major continental population groups, and several AIM panels have been developed for this purpose. However, from these major population groups, Eurasia covers a wide area between two continents that is difficult to differentiate genetically. These populations display a gradual genetic cline from West Europe to South Asia in terms of allele frequency distribution. Although differences have been reported between Europe and South Asia, Middle East populations continue to be a target of further investigations due to the lack of genetic variability, therefore hampering their genetic differentiation from neighboring populations. In the present study, a custom-built ancestry panel was developed to analyze North African and Middle Eastern populations, designated the ‘NAME’ panel. The NAME panel contains 111 SNPs that have patterns of allele frequency differentiation that can distinguish individuals originating in North Africa and the Middle East when combined with a previous set of 126 Global AIM-SNPs.

Original language	English
Journal	Forensic Science International: Genetics
Volume	42
Pages (from-to)	260-267
ISSN	1872-4973
DOIs	https://doi.org/10.1016/j.fsigen.2019.06.010
Publication status	Published - Sept 2019

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Pereira, V., Freire-Aradas, A., Ballard, D., Børsting, C., Diez, V., Pruszkowska-Przybylska, P., Ribeiro, J., Achakzai, N. M., Aliferi, A., Bulbul, O., Perez-Carceles, M. D., Triki-Fendri, S., Rebai, A., Syndercombe-Court, D., Morling, N., Lareu, M., Carracedo, A., The EUROFORGEN-NoE Consortium, & Phillips, C. (2019). Development and validation of the EUROFORGEN NAME (North African and Middle Eastern) ancestry panel. Forensic Science International: Genetics, 42, 260-267. https://doi.org/10.1016/j.fsigen.2019.06.010

Pereira, V, Freire-Aradas, A, Ballard, D, Børsting, C, Diez, V, Pruszkowska-Przybylska, P, Ribeiro, J, Achakzai, NM, Aliferi, A, Bulbul, O, Perez-Carceles, MD, Triki-Fendri, S, Rebai, A, Syndercombe-Court, D, Morling, N, Lareu, M, Carracedo, A, The EUROFORGEN-NoE Consortium & Phillips, C 2019, 'Development and validation of the EUROFORGEN NAME (North African and Middle Eastern) ancestry panel', Forensic Science International: Genetics, vol. 42, pp. 260-267. https://doi.org/10.1016/j.fsigen.2019.06.010

@article{f9eaa2d7973c4701a1fe54e2f76eaae1,

title = "Development and validation of the EUROFORGEN NAME (North African and Middle Eastern) ancestry panel",

abstract = "Inference of biogeographic origin is an important factor in clinical, population and forensic genetics. The information provided by AIMs (Ancestry Informative Markers) can allow the differentiation of major continental population groups, and several AIM panels have been developed for this purpose. However, from these major population groups, Eurasia covers a wide area between two continents that is difficult to differentiate genetically. These populations display a gradual genetic cline from West Europe to South Asia in terms of allele frequency distribution. Although differences have been reported between Europe and South Asia, Middle East populations continue to be a target of further investigations due to the lack of genetic variability, therefore hampering their genetic differentiation from neighboring populations. In the present study, a custom-built ancestry panel was developed to analyze North African and Middle Eastern populations, designated the {\textquoteleft}NAME{\textquoteright} panel. The NAME panel contains 111 SNPs that have patterns of allele frequency differentiation that can distinguish individuals originating in North Africa and the Middle East when combined with a previous set of 126 Global AIM-SNPs.",

author = "Vania Pereira and Ana Freire-Aradas and David Ballard and Claus B{\o}rsting and V. Diez and Paulina Pruszkowska-Przybylska and J. Ribeiro and Achakzai, {Niaz M} and Anastasia Aliferi and Ozlem Bulbul and Perez-Carceles, {Maria D} and Soumaya Triki-Fendri and Ahmed Rebai and D Syndercombe-Court and Niels Morling and Maviky Lareu and Angel Carracedo and {The EUROFORGEN-NoE Consortium} and Christoffer Phillips",

year = "2019",

month = sep,

doi = "10.1016/j.fsigen.2019.06.010",

language = "English",

volume = "42",

pages = "260--267",

journal = "Forensic Science International: Genetics",

issn = "1872-4973",

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T1 - Development and validation of the EUROFORGEN NAME (North African and Middle Eastern) ancestry panel

AU - Pereira, Vania

AU - Freire-Aradas, Ana

AU - Ballard, David

AU - Børsting, Claus

AU - Diez, V.

AU - Pruszkowska-Przybylska, Paulina

AU - Ribeiro, J.

AU - Achakzai, Niaz M

AU - Aliferi, Anastasia

AU - Bulbul, Ozlem

AU - Perez-Carceles, Maria D

AU - Triki-Fendri, Soumaya

AU - Rebai, Ahmed

AU - Syndercombe-Court, D

AU - Morling, Niels

AU - Lareu, Maviky

AU - Carracedo, Angel

AU - The EUROFORGEN-NoE Consortium, null

AU - Phillips, Christoffer

PY - 2019/9

Y1 - 2019/9

N2 - Inference of biogeographic origin is an important factor in clinical, population and forensic genetics. The information provided by AIMs (Ancestry Informative Markers) can allow the differentiation of major continental population groups, and several AIM panels have been developed for this purpose. However, from these major population groups, Eurasia covers a wide area between two continents that is difficult to differentiate genetically. These populations display a gradual genetic cline from West Europe to South Asia in terms of allele frequency distribution. Although differences have been reported between Europe and South Asia, Middle East populations continue to be a target of further investigations due to the lack of genetic variability, therefore hampering their genetic differentiation from neighboring populations. In the present study, a custom-built ancestry panel was developed to analyze North African and Middle Eastern populations, designated the ‘NAME’ panel. The NAME panel contains 111 SNPs that have patterns of allele frequency differentiation that can distinguish individuals originating in North Africa and the Middle East when combined with a previous set of 126 Global AIM-SNPs.

AB - Inference of biogeographic origin is an important factor in clinical, population and forensic genetics. The information provided by AIMs (Ancestry Informative Markers) can allow the differentiation of major continental population groups, and several AIM panels have been developed for this purpose. However, from these major population groups, Eurasia covers a wide area between two continents that is difficult to differentiate genetically. These populations display a gradual genetic cline from West Europe to South Asia in terms of allele frequency distribution. Although differences have been reported between Europe and South Asia, Middle East populations continue to be a target of further investigations due to the lack of genetic variability, therefore hampering their genetic differentiation from neighboring populations. In the present study, a custom-built ancestry panel was developed to analyze North African and Middle Eastern populations, designated the ‘NAME’ panel. The NAME panel contains 111 SNPs that have patterns of allele frequency differentiation that can distinguish individuals originating in North Africa and the Middle East when combined with a previous set of 126 Global AIM-SNPs.

U2 - 10.1016/j.fsigen.2019.06.010

DO - 10.1016/j.fsigen.2019.06.010

M3 - Journal article

C2 - 31404905

SN - 1872-4973

VL - 42

SP - 260

EP - 267

JO - Forensic Science International: Genetics

JF - Forensic Science International: Genetics

ER -

Development and validation of the EUROFORGEN NAME (North African and Middle Eastern) ancestry panel

Abstract

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