Determination of pharmaceuticals in environmental and biological matrices using pressurised liquid extraction - Are we developing sound extraction  methods ?

Hannah Elisabeth Sigrid Runnqvist; Søren Alex Bak; Martin Hansen; Bjarne Styrishave; Bent Halling-Sørensen; Bengt Erland Björklund

doi:10.1016/j.chroma.2010.02.046

Determination of pharmaceuticals in environmental and biological matrices using pressurised liquid extraction - Are we developing sound extraction methods ?

Hannah Elisabeth Sigrid Runnqvist, Søren Alex Bak, Martin Hansen, Bjarne Styrishave, Bent Halling-Sørensen, Bengt Erland Björklund

64 Citations (Scopus)

Abstract

Pressurised liquid extraction (PLE) is now a well established and extensively applied extraction technique in environmental analysis for pollutants such as persistent organic pollutants (POPs). During the past decade, an emerging group of environmentally interesting analytes are pharmaceuticals that are continuingly released into the environment. This class is comprised with compounds of various properties. As the field of the analysis of these compounds grows, an increasing number of PLE methods for pharmaceuticals of varying quality are developed and published. This review summarises the critical PLE parameters during PLE method development and highlight them with examples from recently published papers utilising pressurised liquid extraction for the determination of pharmaceuticals in environmental and biological matrices. These recent methods are summarised and critically discussed with the aim to provide important reflections to alleviate in future PLE development for pharmaceuticals in environmental matrices.

Original language	English
Journal	Journal of Chromatography A
Volume	1217
Issue number	16
Pages (from-to)	2447-2470
ISSN	0021-9673
DOIs	https://doi.org/10.1016/j.chroma.2010.02.046
Publication status	Published - Apr 2010

Keywords

Former Faculty of Pharmaceutical Sciences

Access to Document

10.1016/j.chroma.2010.02.046

Cite this

Determination of pharmaceuticals in environmental and biological matrices using pressurised liquid extraction - Are we developing sound extraction methods ? / Runnqvist, Hannah Elisabeth Sigrid; Bak, Søren Alex; Hansen, Martin et al.
In: Journal of Chromatography A, Vol. 1217, No. 16, 04.2010, p. 2447-2470.

Research output: Contribution to journal › Journal article › Research › peer-review

@article{61de3300494411df928f000ea68e967b,

title = "Determination of pharmaceuticals in environmental and biological matrices using pressurised liquid extraction - Are we developing sound extraction methods ?",

abstract = "Pressurised liquid extraction (PLE) is now a well established and extensively applied extraction technique in environmental analysis for pollutants such as persistent organic pollutants (POPs). During the past decade, an emerging group of environmentally interesting analytes are pharmaceuticals that are continuingly released into the environment. This class is comprised with compounds of various properties. As the field of the analysis of these compounds grows, an increasing number of PLE methods for pharmaceuticals of varying quality are developed and published. This review summarises the critical PLE parameters during PLE method development and highlight them with examples from recently published papers utilising pressurised liquid extraction for the determination of pharmaceuticals in environmental and biological matrices. These recent methods are summarised and critically discussed with the aim to provide important reflections to alleviate in future PLE development for pharmaceuticals in environmental matrices.",

keywords = "Former Faculty of Pharmaceutical Sciences",

author = "Runnqvist, {Hannah Elisabeth Sigrid} and Bak, {S{\o}ren Alex} and Martin Hansen and Bjarne Styrishave and Bent Halling-S{\o}rensen and Bj{\"o}rklund, {Bengt Erland}",

year = "2010",

month = apr,

doi = "10.1016/j.chroma.2010.02.046",

language = "English",

volume = "1217",

pages = "2447--2470",

journal = "Journal of Chromatography A",

issn = "0021-9673",

publisher = "Elsevier",

number = "16",

}

TY - JOUR

T1 - Determination of pharmaceuticals in environmental and biological matrices using pressurised liquid extraction - Are we developing sound extraction methods ?

AU - Runnqvist, Hannah Elisabeth Sigrid

AU - Bak, Søren Alex

AU - Hansen, Martin

AU - Styrishave, Bjarne

AU - Halling-Sørensen, Bent

AU - Björklund, Bengt Erland

PY - 2010/4

Y1 - 2010/4

N2 - Pressurised liquid extraction (PLE) is now a well established and extensively applied extraction technique in environmental analysis for pollutants such as persistent organic pollutants (POPs). During the past decade, an emerging group of environmentally interesting analytes are pharmaceuticals that are continuingly released into the environment. This class is comprised with compounds of various properties. As the field of the analysis of these compounds grows, an increasing number of PLE methods for pharmaceuticals of varying quality are developed and published. This review summarises the critical PLE parameters during PLE method development and highlight them with examples from recently published papers utilising pressurised liquid extraction for the determination of pharmaceuticals in environmental and biological matrices. These recent methods are summarised and critically discussed with the aim to provide important reflections to alleviate in future PLE development for pharmaceuticals in environmental matrices.

AB - Pressurised liquid extraction (PLE) is now a well established and extensively applied extraction technique in environmental analysis for pollutants such as persistent organic pollutants (POPs). During the past decade, an emerging group of environmentally interesting analytes are pharmaceuticals that are continuingly released into the environment. This class is comprised with compounds of various properties. As the field of the analysis of these compounds grows, an increasing number of PLE methods for pharmaceuticals of varying quality are developed and published. This review summarises the critical PLE parameters during PLE method development and highlight them with examples from recently published papers utilising pressurised liquid extraction for the determination of pharmaceuticals in environmental and biological matrices. These recent methods are summarised and critically discussed with the aim to provide important reflections to alleviate in future PLE development for pharmaceuticals in environmental matrices.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1016/j.chroma.2010.02.046

DO - 10.1016/j.chroma.2010.02.046

M3 - Journal article

C2 - 20303086

SN - 0021-9673

VL - 1217

SP - 2447

EP - 2470

JO - Journal of Chromatography A

JF - Journal of Chromatography A

IS - 16

ER -

Determination of pharmaceuticals in environmental and biological matrices using pressurised liquid extraction - Are we developing sound extraction methods ?

Abstract

Keywords

Access to Document

Fingerprint

Cite this