Determination of pharmaceuticals in environmental and biological matrices using pressurised liquid extraction - Are we developing sound extraction  methods ?

Hannah Elisabeth Sigrid Runnqvist; Søren Alex Bak; Martin Hansen; Bjarne Styrishave; Bent Halling-Sørensen; Bengt Erland Björklund

doi:10.1016/j.chroma.2010.02.046

Determination of pharmaceuticals in environmental and biological matrices using pressurised liquid extraction - Are we developing sound extraction methods ?

Hannah Elisabeth Sigrid Runnqvist, Søren Alex Bak, Martin Hansen, Bjarne Styrishave, Bent Halling-Sørensen, Bengt Erland Björklund

64 Citationer (Scopus)

Abstract

Pressurised liquid extraction (PLE) is now a well established and extensively applied extraction technique in environmental analysis for pollutants such as persistent organic pollutants (POPs). During the past decade, an emerging group of environmentally interesting analytes are pharmaceuticals that are continuingly released into the environment. This class is comprised with compounds of various properties. As the field of the analysis of these compounds grows, an increasing number of PLE methods for pharmaceuticals of varying quality are developed and published. This review summarises the critical PLE parameters during PLE method development and highlight them with examples from recently published papers utilising pressurised liquid extraction for the determination of pharmaceuticals in environmental and biological matrices. These recent methods are summarised and critically discussed with the aim to provide important reflections to alleviate in future PLE development for pharmaceuticals in environmental matrices.

Originalsprog	Engelsk
Tidsskrift	Journal of Chromatography A
Vol/bind	1217
Udgave nummer	16
Sider (fra-til)	2447-2470
ISSN	0021-9673
DOI	https://doi.org/10.1016/j.chroma.2010.02.046
Status	Udgivet - apr. 2010

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Determination of pharmaceuticals in environmental and biological matrices using pressurised liquid extraction - Are we developing sound extraction methods ? / Runnqvist, Hannah Elisabeth Sigrid; Bak, Søren Alex; Hansen, Martin et al.
I: Journal of Chromatography A, Bind 1217, Nr. 16, 04.2010, s. 2447-2470.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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abstract = "Pressurised liquid extraction (PLE) is now a well established and extensively applied extraction technique in environmental analysis for pollutants such as persistent organic pollutants (POPs). During the past decade, an emerging group of environmentally interesting analytes are pharmaceuticals that are continuingly released into the environment. This class is comprised with compounds of various properties. As the field of the analysis of these compounds grows, an increasing number of PLE methods for pharmaceuticals of varying quality are developed and published. This review summarises the critical PLE parameters during PLE method development and highlight them with examples from recently published papers utilising pressurised liquid extraction for the determination of pharmaceuticals in environmental and biological matrices. These recent methods are summarised and critically discussed with the aim to provide important reflections to alleviate in future PLE development for pharmaceuticals in environmental matrices.",

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AU - Runnqvist, Hannah Elisabeth Sigrid

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AU - Halling-Sørensen, Bent

AU - Björklund, Bengt Erland

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AB - Pressurised liquid extraction (PLE) is now a well established and extensively applied extraction technique in environmental analysis for pollutants such as persistent organic pollutants (POPs). During the past decade, an emerging group of environmentally interesting analytes are pharmaceuticals that are continuingly released into the environment. This class is comprised with compounds of various properties. As the field of the analysis of these compounds grows, an increasing number of PLE methods for pharmaceuticals of varying quality are developed and published. This review summarises the critical PLE parameters during PLE method development and highlight them with examples from recently published papers utilising pressurised liquid extraction for the determination of pharmaceuticals in environmental and biological matrices. These recent methods are summarised and critically discussed with the aim to provide important reflections to alleviate in future PLE development for pharmaceuticals in environmental matrices.

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Determination of pharmaceuticals in environmental and biological matrices using pressurised liquid extraction - Are we developing sound extraction methods ?

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