Detecting selection needs comparative data

Rasmus Nielsen; Melissa J. Hubisz

doi:10.1038/nature03222

Detecting selection needs comparative data

18 Citations (Scopus)

Abstract

Positive selection at the molecular level is usually indicated by an increase in the ratio of non-synonymous to synonymous substitutions (dN/dS) in comparative data. However, Plotkin et al.¹ describe a new method for detecting positive selection based on a single nucleotide sequence. We show here that this method is particularly sensitive to assumptions regarding the underlying mutational processes and does not provide a reliable way to identify positive selection.

Original language	English
Journal	Nature
Volume	433
Issue number	7023
Pages (from-to)	E6
ISSN	0028-0836
DOIs	https://doi.org/10.1038/nature03222
Publication status	Published - 2005

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10.1038/nature03222

Cite this

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abstract = "Positive selection at the molecular level is usually indicated by an increase in the ratio of non-synonymous to synonymous substitutions (dN/dS) in comparative data. However, Plotkin et al.1 describe a new method for detecting positive selection based on a single nucleotide sequence. We show here that this method is particularly sensitive to assumptions regarding the underlying mutational processes and does not provide a reliable way to identify positive selection.",

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AB - Positive selection at the molecular level is usually indicated by an increase in the ratio of non-synonymous to synonymous substitutions (dN/dS) in comparative data. However, Plotkin et al.1 describe a new method for detecting positive selection based on a single nucleotide sequence. We show here that this method is particularly sensitive to assumptions regarding the underlying mutational processes and does not provide a reliable way to identify positive selection.

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