@article{1f37639074c311dbbee902004c4f4f50,
title = "Detecting selection needs comparative data",
abstract = "Positive selection at the molecular level is usually indicated by an increase in the ratio of non-synonymous to synonymous substitutions (dN/dS) in comparative data. However, Plotkin et al.1 describe a new method for detecting positive selection based on a single nucleotide sequence. We show here that this method is particularly sensitive to assumptions regarding the underlying mutational processes and does not provide a reliable way to identify positive selection.",
author = "Rasmus Nielsen and Hubisz, {Melissa J.}",
year = "2005",
doi = "10.1038/nature03222",
language = "English",
volume = "433",
pages = "E6",
journal = "Nature",
issn = "0028-0836",
publisher = "nature publishing group",
number = "7023",
}