Design and processing of nanogels as delivery systems for peptides and proteins: Therapeutic Delivery

Lærke Arnfast; Claus Greve Madsen; Lene Jorgensen; Stefania Baldursdottir

doi:10.4155/tde.14.38

Design and processing of nanogels as delivery systems for peptides and proteins: Therapeutic Delivery

Lærke Arnfast, Claus Greve Madsen, Lene Jorgensen, Stefania Baldursdottir

18 Citations (Scopus)

Abstract

Nanogels, cross-linked networks of >1 μm in size, are attractive drug-delivery systems, as they not only possess the potential advantages of nanoscale formulations, but also the attractive abilities of a hydrogel; high hydrophilicity, high loading capacity and the potential for biocompatibility and controlled release. The focus of this review is to provide an overview of the recent developments within the nanogel field, and how the chemical design of the nanogel polymer has been found to influence the properties of the nanogel system. Novel nanogel systems are discussed with respect to their type of cross-linkage and their suitability as therapeutic delivery systems, as well as their ability to stabilize the protein/peptide drug.

Original language	English
Journal	Therapeutic Delivery
Volume	5
Issue number	6
Pages (from-to)	691-708
Number of pages	18
ISSN	2041-5990
DOIs	https://doi.org/10.4155/tde.14.38
Publication status	Published - 1 Jun 2014

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10.4155/tde.14.38

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abstract = "Nanogels, cross-linked networks of >1 μm in size, are attractive drug-delivery systems, as they not only possess the potential advantages of nanoscale formulations, but also the attractive abilities of a hydrogel; high hydrophilicity, high loading capacity and the potential for biocompatibility and controlled release. The focus of this review is to provide an overview of the recent developments within the nanogel field, and how the chemical design of the nanogel polymer has been found to influence the properties of the nanogel system. Novel nanogel systems are discussed with respect to their type of cross-linkage and their suitability as therapeutic delivery systems, as well as their ability to stabilize the protein/peptide drug.",

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AU - Arnfast, Lærke

AU - Madsen, Claus Greve

AU - Jorgensen, Lene

AU - Baldursdottir, Stefania

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