TY - JOUR
T1 - Design and processing of nanogels as delivery systems for peptides and proteins
T2 - Therapeutic Delivery
AU - Arnfast, Lærke
AU - Madsen, Claus Greve
AU - Jorgensen, Lene
AU - Baldursdottir, Stefania
PY - 2014/6/1
Y1 - 2014/6/1
N2 - Nanogels, cross-linked networks of >1 μm in size, are attractive drug-delivery systems, as they not only possess the potential advantages of nanoscale formulations, but also the attractive abilities of a hydrogel; high hydrophilicity, high loading capacity and the potential for biocompatibility and controlled release. The focus of this review is to provide an overview of the recent developments within the nanogel field, and how the chemical design of the nanogel polymer has been found to influence the properties of the nanogel system. Novel nanogel systems are discussed with respect to their type of cross-linkage and their suitability as therapeutic delivery systems, as well as their ability to stabilize the protein/peptide drug.
AB - Nanogels, cross-linked networks of >1 μm in size, are attractive drug-delivery systems, as they not only possess the potential advantages of nanoscale formulations, but also the attractive abilities of a hydrogel; high hydrophilicity, high loading capacity and the potential for biocompatibility and controlled release. The focus of this review is to provide an overview of the recent developments within the nanogel field, and how the chemical design of the nanogel polymer has been found to influence the properties of the nanogel system. Novel nanogel systems are discussed with respect to their type of cross-linkage and their suitability as therapeutic delivery systems, as well as their ability to stabilize the protein/peptide drug.
U2 - 10.4155/tde.14.38
DO - 10.4155/tde.14.38
M3 - Journal article
SN - 2041-5990
VL - 5
SP - 691
EP - 708
JO - Therapeutic Delivery
JF - Therapeutic Delivery
IS - 6
ER -