Deposition of a model substance,  Tc E-HIDA, in the oral cavity after administration of lozenges, chewing gum and sublingual tablets

Lona Louring Christrup; S.S. Davis; C.D. Melia; I.R. Wilding; M. Frier; S.N. Rasmussen; N. Washington; C. Andersen

Deposition of a model substance, Tc E-HIDA, in the oral cavity after administration of lozenges, chewing gum and sublingual tablets

Lona Louring Christrup, S.S. Davis, C.D. Melia, I.R. Wilding, M. Frier, S.N. Rasmussen, N. Washington, C. Andersen

14 Citations (Scopus)

Abstract

The deposition and clearance of a model substance, Tc E-HIDA, in the oral cavity/upper oesophagus and in the stomach after administration of lozenges, chewing gum and sublingual tablets has been followed by gamma scintigraphy in a group of healthy male volunteers. Following administration of sublingual tablets, the residence time of the model substance in the oral cavity was significantly longer than following administration of chewing gum. The residence time following administration of lozenges was found to be the shortest.

Original language	English
Journal	International Journal of Pharmaceutics
Volume	66
Issue number	1-3
Pages (from-to)	169-174
Number of pages	6
ISSN	0378-5173
Publication status	Published - 1 Dec 1990

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Christrup, L. L., Davis, S. S., Melia, C. D., Wilding, I. R., Frier, M., Rasmussen, S. N., Washington, N., & Andersen, C. (1990). Deposition of a model substance, Tc E-HIDA, in the oral cavity after administration of lozenges, chewing gum and sublingual tablets. International Journal of Pharmaceutics, 66(1-3), 169-174. http://www.sciencedirect.com/science/article/pii/037851739090396L

Christrup, LL, Davis, SS, Melia, CD, Wilding, IR, Frier, M, Rasmussen, SN, Washington, N & Andersen, C 1990, 'Deposition of a model substance, Tc E-HIDA, in the oral cavity after administration of lozenges, chewing gum and sublingual tablets', International Journal of Pharmaceutics, vol. 66, no. 1-3, pp. 169-174. <http://www.sciencedirect.com/science/article/pii/037851739090396L>

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Deposition of a model substance, Tc E-HIDA, in the oral cavity after administration of lozenges, chewing gum and sublingual tablets

Abstract

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