Dendrimers in Medicine: therapeutic concepts and pharmaceutical challenges

Linping Wu; Mario Ficker; Jørn Bolstad Christensen; Panagiotis N. Trohopoulos; Seyed Moien Moghimi

doi:10.1021/acs.bioconjchem.5b00031

Dendrimers in Medicine: therapeutic concepts and pharmaceutical challenges

Linping Wu, Mario Ficker, Jørn Bolstad Christensen, Panagiotis N. Trohopoulos, Seyed Moien Moghimi

Department of Chemistry

123 Citations (Scopus)

Abstract

Dendrimers are three-dimensional macromolecular structures originating from a central core molecule and surrounded by successive addition of branching layers (generation). These structures exhibit a high degree of molecular uniformity, narrow molecular weight distribution, tunable size and shape characteristics, as well as multivalency. Collectively, these physicochemical characteristics together with advancements in design of biodegradable backbones have conferred many applications to dendrimers in formulation science and nanopharmaceutical developments. These have included the use of dendrimers as pro-drugs and vehicles for solubilization, encapsulation, complexation, delivery, and site-specific targeting of small-molecule drugs, biopharmaceuticals, and contrast agents. We briefly review these advances, paying particular attention to attributes that make dendrimers versatile for drug formulation as well as challenging issues surrounding the future development of dendrimer-based medicines.

Original language	English
Journal	Bioconjugate Chemistry
Volume	26
Issue number	7
Pages (from-to)	1198-1211
Number of pages	14
ISSN	1043-1802
DOIs	https://doi.org/10.1021/acs.bioconjchem.5b00031
Publication status	Published - 15 Jul 2015

Access to Document

10.1021/acs.bioconjchem.5b00031

Cite this

@article{971a869c75bd41e895cdca4b8459a221,

title = "Dendrimers in Medicine: therapeutic concepts and pharmaceutical challenges",

abstract = "Dendrimers are three-dimensional macromolecular structures originating from a central core molecule and surrounded by successive addition of branching layers (generation). These structures exhibit a high degree of molecular uniformity, narrow molecular weight distribution, tunable size and shape characteristics, as well as multivalency. Collectively, these physicochemical characteristics together with advancements in design of biodegradable backbones have conferred many applications to dendrimers in formulation science and nanopharmaceutical developments. These have included the use of dendrimers as pro-drugs and vehicles for solubilization, encapsulation, complexation, delivery, and site-specific targeting of small-molecule drugs, biopharmaceuticals, and contrast agents. We briefly review these advances, paying particular attention to attributes that make dendrimers versatile for drug formulation as well as challenging issues surrounding the future development of dendrimer-based medicines.",

author = "Linping Wu and Mario Ficker and Christensen, {J{\o}rn Bolstad} and Trohopoulos, {Panagiotis N.} and Moghimi, {Seyed Moien}",

year = "2015",

month = jul,

day = "15",

doi = "10.1021/acs.bioconjchem.5b00031",

language = "English",

volume = "26",

pages = "1198--1211",

journal = "Bioconjugate Chemistry",

issn = "1043-1802",

publisher = "American Chemical Society",

number = "7",

}

TY - JOUR

T1 - Dendrimers in Medicine

T2 - therapeutic concepts and pharmaceutical challenges

AU - Wu, Linping

AU - Ficker, Mario

AU - Christensen, Jørn Bolstad

AU - Trohopoulos, Panagiotis N.

AU - Moghimi, Seyed Moien

PY - 2015/7/15

Y1 - 2015/7/15

N2 - Dendrimers are three-dimensional macromolecular structures originating from a central core molecule and surrounded by successive addition of branching layers (generation). These structures exhibit a high degree of molecular uniformity, narrow molecular weight distribution, tunable size and shape characteristics, as well as multivalency. Collectively, these physicochemical characteristics together with advancements in design of biodegradable backbones have conferred many applications to dendrimers in formulation science and nanopharmaceutical developments. These have included the use of dendrimers as pro-drugs and vehicles for solubilization, encapsulation, complexation, delivery, and site-specific targeting of small-molecule drugs, biopharmaceuticals, and contrast agents. We briefly review these advances, paying particular attention to attributes that make dendrimers versatile for drug formulation as well as challenging issues surrounding the future development of dendrimer-based medicines.

AB - Dendrimers are three-dimensional macromolecular structures originating from a central core molecule and surrounded by successive addition of branching layers (generation). These structures exhibit a high degree of molecular uniformity, narrow molecular weight distribution, tunable size and shape characteristics, as well as multivalency. Collectively, these physicochemical characteristics together with advancements in design of biodegradable backbones have conferred many applications to dendrimers in formulation science and nanopharmaceutical developments. These have included the use of dendrimers as pro-drugs and vehicles for solubilization, encapsulation, complexation, delivery, and site-specific targeting of small-molecule drugs, biopharmaceuticals, and contrast agents. We briefly review these advances, paying particular attention to attributes that make dendrimers versatile for drug formulation as well as challenging issues surrounding the future development of dendrimer-based medicines.

U2 - 10.1021/acs.bioconjchem.5b00031

DO - 10.1021/acs.bioconjchem.5b00031

M3 - Journal article

C2 - 25654320

SN - 1043-1802

VL - 26

SP - 1198

EP - 1211

JO - Bioconjugate Chemistry

JF - Bioconjugate Chemistry

IS - 7

ER -

Dendrimers in Medicine: therapeutic concepts and pharmaceutical challenges

Abstract

Access to Document

Fingerprint

Cite this