Dendrimers in Medicine: therapeutic concepts and pharmaceutical challenges

Linping Wu; Mario Ficker; Jørn Bolstad Christensen; Panagiotis N. Trohopoulos; Seyed Moien Moghimi

doi:10.1021/acs.bioconjchem.5b00031

Dendrimers in Medicine: therapeutic concepts and pharmaceutical challenges

Linping Wu, Mario Ficker, Jørn Bolstad Christensen, Panagiotis N. Trohopoulos, Seyed Moien Moghimi

Kemisk Institut

123 Citationer (Scopus)

Abstract

Dendrimers are three-dimensional macromolecular structures originating from a central core molecule and surrounded by successive addition of branching layers (generation). These structures exhibit a high degree of molecular uniformity, narrow molecular weight distribution, tunable size and shape characteristics, as well as multivalency. Collectively, these physicochemical characteristics together with advancements in design of biodegradable backbones have conferred many applications to dendrimers in formulation science and nanopharmaceutical developments. These have included the use of dendrimers as pro-drugs and vehicles for solubilization, encapsulation, complexation, delivery, and site-specific targeting of small-molecule drugs, biopharmaceuticals, and contrast agents. We briefly review these advances, paying particular attention to attributes that make dendrimers versatile for drug formulation as well as challenging issues surrounding the future development of dendrimer-based medicines.

Originalsprog	Engelsk
Tidsskrift	Bioconjugate Chemistry
Vol/bind	26
Udgave nummer	7
Sider (fra-til)	1198-1211
Antal sider	14
ISSN	1043-1802
DOI	https://doi.org/10.1021/acs.bioconjchem.5b00031
Status	Udgivet - 15 jul. 2015

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10.1021/acs.bioconjchem.5b00031

Citationsformater

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T2 - therapeutic concepts and pharmaceutical challenges

AU - Wu, Linping

AU - Ficker, Mario

AU - Christensen, Jørn Bolstad

AU - Trohopoulos, Panagiotis N.

AU - Moghimi, Seyed Moien

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AB - Dendrimers are three-dimensional macromolecular structures originating from a central core molecule and surrounded by successive addition of branching layers (generation). These structures exhibit a high degree of molecular uniformity, narrow molecular weight distribution, tunable size and shape characteristics, as well as multivalency. Collectively, these physicochemical characteristics together with advancements in design of biodegradable backbones have conferred many applications to dendrimers in formulation science and nanopharmaceutical developments. These have included the use of dendrimers as pro-drugs and vehicles for solubilization, encapsulation, complexation, delivery, and site-specific targeting of small-molecule drugs, biopharmaceuticals, and contrast agents. We briefly review these advances, paying particular attention to attributes that make dendrimers versatile for drug formulation as well as challenging issues surrounding the future development of dendrimer-based medicines.

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Dendrimers in Medicine: therapeutic concepts and pharmaceutical challenges

Abstract

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