TY - JOUR
T1 - Dendrimers in Medicine
T2 - therapeutic concepts and pharmaceutical challenges
AU - Wu, Linping
AU - Ficker, Mario
AU - Christensen, Jørn Bolstad
AU - Trohopoulos, Panagiotis N.
AU - Moghimi, Seyed Moien
PY - 2015/7/15
Y1 - 2015/7/15
N2 - Dendrimers are three-dimensional macromolecular structures originating from a central core molecule and surrounded by successive addition of branching layers (generation). These structures exhibit a high degree of molecular uniformity, narrow molecular weight distribution, tunable size and shape characteristics, as well as multivalency. Collectively, these physicochemical characteristics together with advancements in design of biodegradable backbones have conferred many applications to dendrimers in formulation science and nanopharmaceutical developments. These have included the use of dendrimers as pro-drugs and vehicles for solubilization, encapsulation, complexation, delivery, and site-specific targeting of small-molecule drugs, biopharmaceuticals, and contrast agents. We briefly review these advances, paying particular attention to attributes that make dendrimers versatile for drug formulation as well as challenging issues surrounding the future development of dendrimer-based medicines.
AB - Dendrimers are three-dimensional macromolecular structures originating from a central core molecule and surrounded by successive addition of branching layers (generation). These structures exhibit a high degree of molecular uniformity, narrow molecular weight distribution, tunable size and shape characteristics, as well as multivalency. Collectively, these physicochemical characteristics together with advancements in design of biodegradable backbones have conferred many applications to dendrimers in formulation science and nanopharmaceutical developments. These have included the use of dendrimers as pro-drugs and vehicles for solubilization, encapsulation, complexation, delivery, and site-specific targeting of small-molecule drugs, biopharmaceuticals, and contrast agents. We briefly review these advances, paying particular attention to attributes that make dendrimers versatile for drug formulation as well as challenging issues surrounding the future development of dendrimer-based medicines.
U2 - 10.1021/acs.bioconjchem.5b00031
DO - 10.1021/acs.bioconjchem.5b00031
M3 - Journal article
C2 - 25654320
SN - 1043-1802
VL - 26
SP - 1198
EP - 1211
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
IS - 7
ER -