Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification

Kim Henriksen; Mette G Sørensen; Rasmus H Nielsen; Jeppe Gram; Sophie Schaller; Morten Hanefeld Dziegiel; Vincent Everts; Jens Bollerslev; Morten A Karsdal

doi:10.1359/JBMR.050905

Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification

Kim Henriksen, Mette G Sørensen, Rasmus H Nielsen, Jeppe Gram, Sophie Schaller, Morten Hanefeld Dziegiel, Vincent Everts, Jens Bollerslev, Morten A Karsdal

62 Citations (Scopus)

Abstract

Osteoclasts degrade bone matrix by secretion of hydrochloric acid and proteases. We studied the processes involved in the degradation of the organic matrix of bone in detail and found that lysosomal acidification is involved in this process and that MMPs are capable of degrading the organic matrix in the absence of cathepsin K.

Original language	English
Journal	Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume	21
Issue number	1
Pages (from-to)	58-66
Number of pages	9
ISSN	0884-0431
DOIs	https://doi.org/10.1359/JBMR.050905
Publication status	Published - Jan 2006

Keywords

Adult
Aged
Bone Resorption
Cathepsin K
Cathepsins
Cells, Cultured
Chloride Channels
Chromosome Disorders
Collagenases
Female
Humans
Male
Middle Aged
Osteoclasts
Osteoporosis
Vacuolar Proton-Translocating ATPases

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10.1359/JBMR.050905

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Henriksen, K., Sørensen, M. G., Nielsen, R. H., Gram, J., Schaller, S., Dziegiel, M. H., Everts, V., Bollerslev, J., & Karsdal, M. A. (2006). Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 21(1), 58-66. https://doi.org/10.1359/JBMR.050905

Degradation of the organic phase of bone by osteoclasts : a secondary role for lysosomal acidification. / Henriksen, Kim; Sørensen, Mette G; Nielsen, Rasmus H et al.

In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 21, No. 1, 01.2006, p. 58-66.

Research output: Contribution to journal › Journal article › Research › peer-review

Henriksen, K, Sørensen, MG, Nielsen, RH, Gram, J, Schaller, S, Dziegiel, MH, Everts, V, Bollerslev, J & Karsdal, MA 2006, 'Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification', Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, vol. 21, no. 1, pp. 58-66. https://doi.org/10.1359/JBMR.050905

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abstract = "Osteoclasts degrade bone matrix by secretion of hydrochloric acid and proteases. We studied the processes involved in the degradation of the organic matrix of bone in detail and found that lysosomal acidification is involved in this process and that MMPs are capable of degrading the organic matrix in the absence of cathepsin K.",

keywords = "Adult, Aged, Bone Resorption, Cathepsin K, Cathepsins, Cells, Cultured, Chloride Channels, Chromosome Disorders, Collagenases, Female, Humans, Male, Middle Aged, Osteoclasts, Osteoporosis, Vacuolar Proton-Translocating ATPases",

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T2 - a secondary role for lysosomal acidification

AU - Henriksen, Kim

AU - Sørensen, Mette G

AU - Nielsen, Rasmus H

AU - Gram, Jeppe

AU - Schaller, Sophie

AU - Dziegiel, Morten Hanefeld

AU - Everts, Vincent

AU - Bollerslev, Jens

AU - Karsdal, Morten A

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AB - Osteoclasts degrade bone matrix by secretion of hydrochloric acid and proteases. We studied the processes involved in the degradation of the organic matrix of bone in detail and found that lysosomal acidification is involved in this process and that MMPs are capable of degrading the organic matrix in the absence of cathepsin K.

KW - Adult

KW - Aged

KW - Bone Resorption

KW - Cathepsin K

KW - Cathepsins

KW - Cells, Cultured

KW - Chloride Channels

KW - Chromosome Disorders

KW - Collagenases

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Osteoclasts

KW - Osteoporosis

KW - Vacuolar Proton-Translocating ATPases

U2 - 10.1359/JBMR.050905

DO - 10.1359/JBMR.050905

M3 - Journal article

C2 - 16355274

SN - 0884-0431

VL - 21

SP - 58

EP - 66

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

IS - 1

ER -

Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification

Abstract

Keywords

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