Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification

Kim Henriksen; Mette G Sørensen; Rasmus H Nielsen; Jeppe Gram; Sophie Schaller; Morten Hanefeld Dziegiel; Vincent Everts; Jens Bollerslev; Morten A Karsdal

doi:10.1359/JBMR.050905

Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification

Kim Henriksen, Mette G Sørensen, Rasmus H Nielsen, Jeppe Gram, Sophie Schaller, Morten Hanefeld Dziegiel, Vincent Everts, Jens Bollerslev, Morten A Karsdal

62 Citationer (Scopus)

Abstract

Osteoclasts degrade bone matrix by secretion of hydrochloric acid and proteases. We studied the processes involved in the degradation of the organic matrix of bone in detail and found that lysosomal acidification is involved in this process and that MMPs are capable of degrading the organic matrix in the absence of cathepsin K.

Originalsprog	Engelsk
Tidsskrift	Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Vol/bind	21
Udgave nummer	1
Sider (fra-til)	58-66
Antal sider	9
ISSN	0884-0431
DOI	https://doi.org/10.1359/JBMR.050905
Status	Udgivet - jan. 2006

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10.1359/JBMR.050905

Citationsformater

Henriksen, K., Sørensen, M. G., Nielsen, R. H., Gram, J., Schaller, S., Dziegiel, M. H., Everts, V., Bollerslev, J., & Karsdal, M. A. (2006). Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 21(1), 58-66. https://doi.org/10.1359/JBMR.050905

Degradation of the organic phase of bone by osteoclasts : a secondary role for lysosomal acidification. / Henriksen, Kim; Sørensen, Mette G; Nielsen, Rasmus H et al.

I: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Bind 21, Nr. 1, 01.2006, s. 58-66.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Henriksen, K, Sørensen, MG, Nielsen, RH, Gram, J, Schaller, S, Dziegiel, MH, Everts, V, Bollerslev, J & Karsdal, MA 2006, 'Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification', Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, bind 21, nr. 1, s. 58-66. https://doi.org/10.1359/JBMR.050905

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abstract = "Osteoclasts degrade bone matrix by secretion of hydrochloric acid and proteases. We studied the processes involved in the degradation of the organic matrix of bone in detail and found that lysosomal acidification is involved in this process and that MMPs are capable of degrading the organic matrix in the absence of cathepsin K.",

keywords = "Adult, Aged, Bone Resorption, Cathepsin K, Cathepsins, Cells, Cultured, Chloride Channels, Chromosome Disorders, Collagenases, Female, Humans, Male, Middle Aged, Osteoclasts, Osteoporosis, Vacuolar Proton-Translocating ATPases",

author = "Kim Henriksen and S{\o}rensen, {Mette G} and Nielsen, {Rasmus H} and Jeppe Gram and Sophie Schaller and Dziegiel, {Morten Hanefeld} and Vincent Everts and Jens Bollerslev and Karsdal, {Morten A}",

year = "2006",

month = jan,

doi = "10.1359/JBMR.050905",

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T1 - Degradation of the organic phase of bone by osteoclasts

T2 - a secondary role for lysosomal acidification

AU - Henriksen, Kim

AU - Sørensen, Mette G

AU - Nielsen, Rasmus H

AU - Gram, Jeppe

AU - Schaller, Sophie

AU - Dziegiel, Morten Hanefeld

AU - Everts, Vincent

AU - Bollerslev, Jens

AU - Karsdal, Morten A

PY - 2006/1

Y1 - 2006/1

N2 - Osteoclasts degrade bone matrix by secretion of hydrochloric acid and proteases. We studied the processes involved in the degradation of the organic matrix of bone in detail and found that lysosomal acidification is involved in this process and that MMPs are capable of degrading the organic matrix in the absence of cathepsin K.

AB - Osteoclasts degrade bone matrix by secretion of hydrochloric acid and proteases. We studied the processes involved in the degradation of the organic matrix of bone in detail and found that lysosomal acidification is involved in this process and that MMPs are capable of degrading the organic matrix in the absence of cathepsin K.

KW - Adult

KW - Aged

KW - Bone Resorption

KW - Cathepsin K

KW - Cathepsins

KW - Cells, Cultured

KW - Chloride Channels

KW - Chromosome Disorders

KW - Collagenases

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Osteoclasts

KW - Osteoporosis

KW - Vacuolar Proton-Translocating ATPases

U2 - 10.1359/JBMR.050905

DO - 10.1359/JBMR.050905

M3 - Journal article

C2 - 16355274

SN - 0884-0431

VL - 21

SP - 58

EP - 66

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

IS - 1

ER -

Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification

Abstract

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