Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis.

Eva Julià; Xavier Montalban; Hammad Al-Zayat; Shohreh Issazadeh-Navikas; Robert Goertsches; Roland Martin; Manuel Comabella

doi:10.1016/j.jneuroim.2006.07.001

Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis.

Eva Julià, Xavier Montalban, Hammad Al-Zayat, Shohreh Issazadeh-Navikas, Robert Goertsches, Roland Martin, Manuel Comabella

15 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. METHODS: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. RESULTS: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. INTERPRETATION: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS.

Original language	English
Journal	Journal of Neuroimmunology
Volume	180
Issue number	1-2
Pages (from-to)	147-58
Number of pages	11
ISSN	0165-5728
DOIs	https://doi.org/10.1016/j.jneuroim.2006.07.001
Publication status	Published - 2006

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10.1016/j.jneuroim.2006.07.001

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@article{992c11d057cc11dd8d9f000ea68e967b,

title = "Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis.",

abstract = "OBJECTIVE: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. METHODS: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. RESULTS: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. INTERPRETATION: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS.",

author = "Eva Juli{\`a} and Xavier Montalban and Hammad Al-Zayat and Shohreh Issazadeh-Navikas and Robert Goertsches and Roland Martin and Manuel Comabella",

note = "Keywords: Adult; Aged; Antigens, CD; Antigens, CD95; Antigens, Differentiation, T-Lymphocyte; Apoptosis; Autoimmunity; CD4-Positive T-Lymphocytes; Cell Survival; Chemotaxis, Leukocyte; Down-Regulation; Fas Ligand Protein; Female; Humans; Immunity, Cellular; Male; Middle Aged; Multiple Sclerosis; Proto-Oncogene Proteins c-bcl-2; Receptors, CCR5; TNF Receptor-Associated Death Domain Protein; bcl-2-Associated X Protein",

year = "2006",

doi = "10.1016/j.jneuroim.2006.07.001",

language = "English",

volume = "180",

pages = "147--58",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis.

AU - Julià, Eva

AU - Montalban, Xavier

AU - Al-Zayat, Hammad

AU - Issazadeh-Navikas, Shohreh

AU - Goertsches, Robert

AU - Martin, Roland

AU - Comabella, Manuel

N1 - Keywords: Adult; Aged; Antigens, CD; Antigens, CD95; Antigens, Differentiation, T-Lymphocyte; Apoptosis; Autoimmunity; CD4-Positive T-Lymphocytes; Cell Survival; Chemotaxis, Leukocyte; Down-Regulation; Fas Ligand Protein; Female; Humans; Immunity, Cellular; Male; Middle Aged; Multiple Sclerosis; Proto-Oncogene Proteins c-bcl-2; Receptors, CCR5; TNF Receptor-Associated Death Domain Protein; bcl-2-Associated X Protein

PY - 2006

Y1 - 2006

N2 - OBJECTIVE: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. METHODS: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. RESULTS: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. INTERPRETATION: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS.

AB - OBJECTIVE: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. METHODS: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. RESULTS: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. INTERPRETATION: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS.

U2 - 10.1016/j.jneuroim.2006.07.001

DO - 10.1016/j.jneuroim.2006.07.001

M3 - Journal article

C2 - 16899302

SN - 0165-5728

VL - 180

SP - 147

EP - 158

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis.

Abstract

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