TY - JOUR
T1 - Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis.
AU - Julià, Eva
AU - Montalban, Xavier
AU - Al-Zayat, Hammad
AU - Issazadeh-Navikas, Shohreh
AU - Goertsches, Robert
AU - Martin, Roland
AU - Comabella, Manuel
N1 - Keywords: Adult; Aged; Antigens, CD; Antigens, CD95; Antigens, Differentiation, T-Lymphocyte; Apoptosis; Autoimmunity; CD4-Positive T-Lymphocytes; Cell Survival; Chemotaxis, Leukocyte; Down-Regulation; Fas Ligand Protein; Female; Humans; Immunity, Cellular; Male; Middle Aged; Multiple Sclerosis; Proto-Oncogene Proteins c-bcl-2; Receptors, CCR5; TNF Receptor-Associated Death Domain Protein; bcl-2-Associated X Protein
PY - 2006
Y1 - 2006
N2 - OBJECTIVE: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. METHODS: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. RESULTS: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. INTERPRETATION: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS.
AB - OBJECTIVE: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. METHODS: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. RESULTS: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. INTERPRETATION: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS.
U2 - 10.1016/j.jneuroim.2006.07.001
DO - 10.1016/j.jneuroim.2006.07.001
M3 - Journal article
C2 - 16899302
SN - 0165-5728
VL - 180
SP - 147
EP - 158
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -