Cytophilic Antibodies Against Key Plasmodium falciparum Blood Stage Antigens Contribute to Protection Against Clinical Malaria in a High Transmission Region of Eastern India

Ikhlaq Hussain Kana; Asier Garcia Senosiain; Susheel Singh; Regis Wendpayangde Tiendrebeogo; Bishwanath Chourasia; Pawan Malhotra; Surya Kant Sharma; Manoj K Das; Subhash Singh; Bright Adu; Michael Theisen

doi:10.1093/infdis/jiy258

Cytophilic Antibodies Against Key Plasmodium falciparum Blood Stage Antigens Contribute to Protection Against Clinical Malaria in a High Transmission Region of Eastern India

Ikhlaq Hussain Kana, Asier Garcia Senosiain, Susheel Singh, Regis Wendpayangde Tiendrebeogo, Bishwanath Chourasia, Pawan Malhotra, Surya Kant Sharma, Manoj K Das, Subhash Singh, Bright Adu, Michael Theisen

14 Citations (Scopus)

Abstract

Background. The collection of clinical data from a tribal population in a malaria-endemic area of India suggests the occurrence of naturally acquired immunity (NAI) against Plasmodium falciparum malaria. Methods. Quantity and functionality of immunoglobulin G (IgG) antibodies against intact merozoites and recombinant proteins were assessed in a 13-month longitudinal cohort study of 121 individuals, 3-60 years of age. Results. Opsonic phagocytosis of merozoites activity was strongly associated (hazard ratio [HR] = 0.34; 95% confidence interval [CI] = .18-.66; P = .0013) with protection against febrile malaria. Of the different IgG subclasses, only IgG3 antibodies against intact whole merozoites was significantly associated with protection against febrile malaria (HR = 0.47; 95% CI = .26-.86; P = .01). Furthermore, a combination of IgG3 antibody responses against Pf12, MSP3.7, MSP3.3, and MSP2FC27 was strongly associated with protection against febrile malaria (HR = 0.15; 95% CI, .06-.37; P = .0001). Conclusions. These data suggest that NAI may, at least in part, be explained by opsonic phagocytosis of merozoites and IgG3 responses against whole merozoites, and in particular to a combination of 4 antigens is critical in this population. These results may have implications in the development of a subunit malaria vaccine.

Original language	English
Journal	The Journal of Infectious Diseases
Volume	218
Issue number	6
Pages (from-to)	956-965
ISSN	0022-1899
DOIs	https://doi.org/10.1093/infdis/jiy258
Publication status	Published - 14 Aug 2018

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Kana, I. H., Garcia Senosiain, A., Singh, S., Tiendrebeogo, R. W., Chourasia, B., Malhotra, P., Sharma, S. K., Das, M. K., Singh, S., Adu, B., & Theisen, M. (2018). Cytophilic Antibodies Against Key Plasmodium falciparum Blood Stage Antigens Contribute to Protection Against Clinical Malaria in a High Transmission Region of Eastern India. The Journal of Infectious Diseases, 218(6), 956-965. https://doi.org/10.1093/infdis/jiy258

Cytophilic Antibodies Against Key Plasmodium falciparum Blood Stage Antigens Contribute to Protection Against Clinical Malaria in a High Transmission Region of Eastern India. / Kana, Ikhlaq Hussain; Garcia Senosiain, Asier; Singh, Susheel et al.

In: The Journal of Infectious Diseases, Vol. 218, No. 6, 14.08.2018, p. 956-965.

Research output: Contribution to journal › Journal article › Research › peer-review

Kana, IH, Garcia Senosiain, A, Singh, S , Tiendrebeogo, RW , Chourasia, B, Malhotra, P, Sharma, SK, Das, MK, Singh, S, Adu, B & Theisen, M 2018, 'Cytophilic Antibodies Against Key Plasmodium falciparum Blood Stage Antigens Contribute to Protection Against Clinical Malaria in a High Transmission Region of Eastern India', The Journal of Infectious Diseases, vol. 218, no. 6, pp. 956-965. https://doi.org/10.1093/infdis/jiy258

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title = "Cytophilic Antibodies Against Key Plasmodium falciparum Blood Stage Antigens Contribute to Protection Against Clinical Malaria in a High Transmission Region of Eastern India",

abstract = "Background. The collection of clinical data from a tribal population in a malaria-endemic area of India suggests the occurrence of naturally acquired immunity (NAI) against Plasmodium falciparum malaria. Methods. Quantity and functionality of immunoglobulin G (IgG) antibodies against intact merozoites and recombinant proteins were assessed in a 13-month longitudinal cohort study of 121 individuals, 3-60 years of age. Results. Opsonic phagocytosis of merozoites activity was strongly associated (hazard ratio [HR] = 0.34; 95% confidence interval [CI] = .18-.66; P = .0013) with protection against febrile malaria. Of the different IgG subclasses, only IgG3 antibodies against intact whole merozoites was significantly associated with protection against febrile malaria (HR = 0.47; 95% CI = .26-.86; P = .01). Furthermore, a combination of IgG3 antibody responses against Pf12, MSP3.7, MSP3.3, and MSP2FC27 was strongly associated with protection against febrile malaria (HR = 0.15; 95% CI, .06-.37; P = .0001). Conclusions. These data suggest that NAI may, at least in part, be explained by opsonic phagocytosis of merozoites and IgG3 responses against whole merozoites, and in particular to a combination of 4 antigens is critical in this population. These results may have implications in the development of a subunit malaria vaccine.",

author = "Kana, {Ikhlaq Hussain} and {Garcia Senosiain}, Asier and Susheel Singh and Tiendrebeogo, {Regis Wendpayangde} and Bishwanath Chourasia and Pawan Malhotra and Sharma, {Surya Kant} and Das, {Manoj K} and Subhash Singh and Bright Adu and Michael Theisen",

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AU - Kana, Ikhlaq Hussain

AU - Garcia Senosiain, Asier

AU - Singh, Susheel

AU - Tiendrebeogo, Regis Wendpayangde

AU - Chourasia, Bishwanath

AU - Malhotra, Pawan

AU - Sharma, Surya Kant

AU - Das, Manoj K

AU - Singh, Subhash

AU - Adu, Bright

AU - Theisen, Michael

PY - 2018/8/14

Y1 - 2018/8/14

N2 - Background. The collection of clinical data from a tribal population in a malaria-endemic area of India suggests the occurrence of naturally acquired immunity (NAI) against Plasmodium falciparum malaria. Methods. Quantity and functionality of immunoglobulin G (IgG) antibodies against intact merozoites and recombinant proteins were assessed in a 13-month longitudinal cohort study of 121 individuals, 3-60 years of age. Results. Opsonic phagocytosis of merozoites activity was strongly associated (hazard ratio [HR] = 0.34; 95% confidence interval [CI] = .18-.66; P = .0013) with protection against febrile malaria. Of the different IgG subclasses, only IgG3 antibodies against intact whole merozoites was significantly associated with protection against febrile malaria (HR = 0.47; 95% CI = .26-.86; P = .01). Furthermore, a combination of IgG3 antibody responses against Pf12, MSP3.7, MSP3.3, and MSP2FC27 was strongly associated with protection against febrile malaria (HR = 0.15; 95% CI, .06-.37; P = .0001). Conclusions. These data suggest that NAI may, at least in part, be explained by opsonic phagocytosis of merozoites and IgG3 responses against whole merozoites, and in particular to a combination of 4 antigens is critical in this population. These results may have implications in the development of a subunit malaria vaccine.

AB - Background. The collection of clinical data from a tribal population in a malaria-endemic area of India suggests the occurrence of naturally acquired immunity (NAI) against Plasmodium falciparum malaria. Methods. Quantity and functionality of immunoglobulin G (IgG) antibodies against intact merozoites and recombinant proteins were assessed in a 13-month longitudinal cohort study of 121 individuals, 3-60 years of age. Results. Opsonic phagocytosis of merozoites activity was strongly associated (hazard ratio [HR] = 0.34; 95% confidence interval [CI] = .18-.66; P = .0013) with protection against febrile malaria. Of the different IgG subclasses, only IgG3 antibodies against intact whole merozoites was significantly associated with protection against febrile malaria (HR = 0.47; 95% CI = .26-.86; P = .01). Furthermore, a combination of IgG3 antibody responses against Pf12, MSP3.7, MSP3.3, and MSP2FC27 was strongly associated with protection against febrile malaria (HR = 0.15; 95% CI, .06-.37; P = .0001). Conclusions. These data suggest that NAI may, at least in part, be explained by opsonic phagocytosis of merozoites and IgG3 responses against whole merozoites, and in particular to a combination of 4 antigens is critical in this population. These results may have implications in the development of a subunit malaria vaccine.

U2 - 10.1093/infdis/jiy258

DO - 10.1093/infdis/jiy258

M3 - Journal article

C2 - 29733355

SN - 0022-1899

VL - 218

SP - 956

EP - 965

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 6

ER -

Cytophilic Antibodies Against Key Plasmodium falciparum Blood Stage Antigens Contribute to Protection Against Clinical Malaria in a High Transmission Region of Eastern India

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