Abstract
Serotonin 2A receptors have been implicated in various psychophysiological functions and disorders such as depression, Alzheimer's disease, or schizophrenia. Therefore, neuroimaging of this specific receptor is of significant clinical interest, and it is not surprising that many attempts have been made to develop a suitable 5-HT2AR positron emission tomography-tracer. In this review, we give an overview on the precursor, reference compound synthesis, and the preparation of promising 5-HT2AR radiopharmaceuticals applied in positron emission tomography. We also highlight possible learning outcomes that can be made from these tracer development processes. This review gives an overview on the precursor, reference compound synthesis, and preparation of most promising 5-HT2AR radiopharmaceuticals applied in positron emission tomography. We also highlight possible learning outcomes that can be made from these tracer development processes.
| Original language | English |
|---|---|
| Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
| Volume | 58 |
| Issue number | 7 |
| Pages (from-to) | 265-73 |
| Number of pages | 9 |
| ISSN | 0362-4803 |
| DOIs | |
| Publication status | Published - 15 Jun 2015 |