Current radiosynthesis strategies for 5-HT2A receptor PET tracers

Matthias M Herth; Gitte M Knudsen

doi:10.1002/jlcr.3288

Current radiosynthesis strategies for 5-HT2A receptor PET tracers

13 Citationer (Scopus)

Abstract

Serotonin 2A receptors have been implicated in various psychophysiological functions and disorders such as depression, Alzheimer's disease, or schizophrenia. Therefore, neuroimaging of this specific receptor is of significant clinical interest, and it is not surprising that many attempts have been made to develop a suitable 5-HT_2AR positron emission tomography-tracer. In this review, we give an overview on the precursor, reference compound synthesis, and the preparation of promising 5-HT_2AR radiopharmaceuticals applied in positron emission tomography. We also highlight possible learning outcomes that can be made from these tracer development processes. This review gives an overview on the precursor, reference compound synthesis, and preparation of most promising 5-HT2AR radiopharmaceuticals applied in positron emission tomography. We also highlight possible learning outcomes that can be made from these tracer development processes.

Originalsprog	Engelsk
Tidsskrift	Journal of Labelled Compounds and Radiopharmaceuticals
Vol/bind	58
Udgave nummer	7
Sider (fra-til)	265-73
Antal sider	9
ISSN	0362-4803
DOI	https://doi.org/10.1002/jlcr.3288
Status	Udgivet - 15 jun. 2015

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10.1002/jlcr.3288

Citationsformater

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abstract = "Serotonin 2A receptors have been implicated in various psychophysiological functions and disorders such as depression, Alzheimer's disease, or schizophrenia. Therefore, neuroimaging of this specific receptor is of significant clinical interest, and it is not surprising that many attempts have been made to develop a suitable 5-HT2AR positron emission tomography-tracer. In this review, we give an overview on the precursor, reference compound synthesis, and the preparation of promising 5-HT2AR radiopharmaceuticals applied in positron emission tomography. We also highlight possible learning outcomes that can be made from these tracer development processes. This review gives an overview on the precursor, reference compound synthesis, and preparation of most promising 5-HT2AR radiopharmaceuticals applied in positron emission tomography. We also highlight possible learning outcomes that can be made from these tracer development processes.",

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AU - Knudsen, Gitte M

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N2 - Serotonin 2A receptors have been implicated in various psychophysiological functions and disorders such as depression, Alzheimer's disease, or schizophrenia. Therefore, neuroimaging of this specific receptor is of significant clinical interest, and it is not surprising that many attempts have been made to develop a suitable 5-HT2AR positron emission tomography-tracer. In this review, we give an overview on the precursor, reference compound synthesis, and the preparation of promising 5-HT2AR radiopharmaceuticals applied in positron emission tomography. We also highlight possible learning outcomes that can be made from these tracer development processes. This review gives an overview on the precursor, reference compound synthesis, and preparation of most promising 5-HT2AR radiopharmaceuticals applied in positron emission tomography. We also highlight possible learning outcomes that can be made from these tracer development processes.

AB - Serotonin 2A receptors have been implicated in various psychophysiological functions and disorders such as depression, Alzheimer's disease, or schizophrenia. Therefore, neuroimaging of this specific receptor is of significant clinical interest, and it is not surprising that many attempts have been made to develop a suitable 5-HT2AR positron emission tomography-tracer. In this review, we give an overview on the precursor, reference compound synthesis, and the preparation of promising 5-HT2AR radiopharmaceuticals applied in positron emission tomography. We also highlight possible learning outcomes that can be made from these tracer development processes. This review gives an overview on the precursor, reference compound synthesis, and preparation of most promising 5-HT2AR radiopharmaceuticals applied in positron emission tomography. We also highlight possible learning outcomes that can be made from these tracer development processes.

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JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

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Current radiosynthesis strategies for 5-HT2A receptor PET tracers

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