Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis

Sjors A. Koppes; Kristiane A. Engebretsen; Tove Agner; Irena Angelova-Fischer; Teresa Berents; Johanna Brandner; Richard Brans; Maja Lisa Clausen; Edith Hummler; Ivone Jakasa; Ružica Jurakić-Tončic; Swen M. John; Denis Khnykin; Sonja Molin; Jan O. Holm; Sari Suomela; Hermann Josef Thierse; Sanja Kezic; Stefan F. Martin; Jacob P. Thyssen

doi:10.1111/cod.12789

Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis

Sjors A. Koppes, Kristiane A. Engebretsen, Tove Agner, Irena Angelova-Fischer, Teresa Berents, Johanna Brandner, Richard Brans, Maja Lisa Clausen, Edith Hummler, Ivone Jakasa, Ružica Jurakić-Tončic, Swen M. John, Denis Khnykin, Sonja Molin, Jan O. Holm, Sari Suomela, Hermann Josef Thierse, Sanja Kezic, Stefan F. Martin, Jacob P. Thyssen^*

^*Corresponding author for this work

Department of Clinical Medicine

37 Citations (Scopus)

Abstract

Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described.

Original language	English
Journal	Contact Dermatitis
Volume	77
Issue number	1
Pages (from-to)	1-16
Number of pages	16
ISSN	0105-1873
DOIs	https://doi.org/10.1111/cod.12789
Publication status	Published - Jul 2017

Keywords

allergic contact dermatitis
biomarkers
contact allergy
contact sensitization

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Koppes, S. A., Engebretsen, K. A., Agner, T., Angelova-Fischer, I., Berents, T., Brandner, J., Brans, R., Clausen, M. L., Hummler, E., Jakasa, I., Jurakić-Tončic, R., John, S. M., Khnykin, D., Molin, S., Holm, J. O., Suomela, S., Thierse, H. J., Kezic, S., Martin, S. F., & Thyssen, J. P. (2017). Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis. Contact Dermatitis, 77(1), 1-16. https://doi.org/10.1111/cod.12789

Koppes, SA, Engebretsen, KA, Agner, T, Angelova-Fischer, I, Berents, T, Brandner, J, Brans, R, Clausen, ML, Hummler, E, Jakasa, I, Jurakić-Tončic, R, John, SM, Khnykin, D, Molin, S, Holm, JO, Suomela, S, Thierse, HJ, Kezic, S, Martin, SF & Thyssen, JP 2017, 'Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis', Contact Dermatitis, vol. 77, no. 1, pp. 1-16. https://doi.org/10.1111/cod.12789

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title = "Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis",

abstract = "Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described.",

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AU - Koppes, Sjors A.

AU - Engebretsen, Kristiane A.

AU - Agner, Tove

AU - Angelova-Fischer, Irena

AU - Berents, Teresa

AU - Brandner, Johanna

AU - Brans, Richard

AU - Clausen, Maja Lisa

AU - Hummler, Edith

AU - Jakasa, Ivone

AU - Jurakić-Tončic, Ružica

AU - John, Swen M.

AU - Khnykin, Denis

AU - Molin, Sonja

AU - Holm, Jan O.

AU - Suomela, Sari

AU - Thierse, Hermann Josef

AU - Kezic, Sanja

AU - Martin, Stefan F.

AU - Thyssen, Jacob P.

PY - 2017/7

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N2 - Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described.

AB - Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described.

KW - allergic contact dermatitis

KW - biomarkers

KW - contact allergy

KW - contact sensitization

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DO - 10.1111/cod.12789

M3 - Review

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AN - SCOPUS:85018897672

SN - 0105-1873

VL - 77

SP - 1

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JO - Contact Dermatitis

JF - Contact Dermatitis

IS - 1

ER -

Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis

Abstract

Keywords

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