Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis

Sjors A. Koppes; Kristiane A. Engebretsen; Tove Agner; Irena Angelova-Fischer; Teresa Berents; Johanna Brandner; Richard Brans; Maja Lisa Clausen; Edith Hummler; Ivone Jakasa; Ružica Jurakić-Tončic; Swen M. John; Denis Khnykin; Sonja Molin; Jan O. Holm; Sari Suomela; Hermann Josef Thierse; Sanja Kezic; Stefan F. Martin; Jacob P. Thyssen

doi:10.1111/cod.12789

Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis

Sjors A. Koppes, Kristiane A. Engebretsen, Tove Agner, Irena Angelova-Fischer, Teresa Berents, Johanna Brandner, Richard Brans, Maja Lisa Clausen, Edith Hummler, Ivone Jakasa, Ružica Jurakić-Tončic, Swen M. John, Denis Khnykin, Sonja Molin, Jan O. Holm, Sari Suomela, Hermann Josef Thierse, Sanja Kezic, Stefan F. Martin, Jacob P. Thyssen^*

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

37 Citationer (Scopus)

Abstract

Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described.

Originalsprog	Engelsk
Tidsskrift	Contact Dermatitis
Vol/bind	77
Udgave nummer	1
Sider (fra-til)	1-16
Antal sider	16
ISSN	0105-1873
DOI	https://doi.org/10.1111/cod.12789
Status	Udgivet - jul. 2017

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10.1111/cod.12789

cod.12789Forlagets udgivne version, 711 KB

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Koppes, S. A., Engebretsen, K. A., Agner, T., Angelova-Fischer, I., Berents, T., Brandner, J., Brans, R., Clausen, M. L., Hummler, E., Jakasa, I., Jurakić-Tončic, R., John, S. M., Khnykin, D., Molin, S., Holm, J. O., Suomela, S., Thierse, H. J., Kezic, S., Martin, S. F., & Thyssen, J. P. (2017). Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis. Contact Dermatitis, 77(1), 1-16. https://doi.org/10.1111/cod.12789

Koppes, SA, Engebretsen, KA, Agner, T, Angelova-Fischer, I, Berents, T, Brandner, J, Brans, R, Clausen, ML, Hummler, E, Jakasa, I, Jurakić-Tončic, R, John, SM, Khnykin, D, Molin, S, Holm, JO, Suomela, S, Thierse, HJ, Kezic, S, Martin, SF & Thyssen, JP 2017, 'Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis', Contact Dermatitis, bind 77, nr. 1, s. 1-16. https://doi.org/10.1111/cod.12789

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title = "Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis",

abstract = "Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described.",

keywords = "allergic contact dermatitis, biomarkers, contact allergy, contact sensitization",

author = "Koppes, {Sjors A.} and Engebretsen, {Kristiane A.} and Tove Agner and Irena Angelova-Fischer and Teresa Berents and Johanna Brandner and Richard Brans and Clausen, {Maja Lisa} and Edith Hummler and Ivone Jakasa and Ru{\v z}ica Juraki{\'c}-Ton{\v c}ic and John, {Swen M.} and Denis Khnykin and Sonja Molin and Holm, {Jan O.} and Sari Suomela and Thierse, {Hermann Josef} and Sanja Kezic and Martin, {Stefan F.} and Thyssen, {Jacob P.}",

year = "2017",

month = jul,

doi = "10.1111/cod.12789",

language = "English",

volume = "77",

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journal = "Contact Dermatitis",

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T1 - Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis

AU - Koppes, Sjors A.

AU - Engebretsen, Kristiane A.

AU - Agner, Tove

AU - Angelova-Fischer, Irena

AU - Berents, Teresa

AU - Brandner, Johanna

AU - Brans, Richard

AU - Clausen, Maja Lisa

AU - Hummler, Edith

AU - Jakasa, Ivone

AU - Jurakić-Tončic, Ružica

AU - John, Swen M.

AU - Khnykin, Denis

AU - Molin, Sonja

AU - Holm, Jan O.

AU - Suomela, Sari

AU - Thierse, Hermann Josef

AU - Kezic, Sanja

AU - Martin, Stefan F.

AU - Thyssen, Jacob P.

PY - 2017/7

Y1 - 2017/7

N2 - Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described.

AB - Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described.

KW - allergic contact dermatitis

KW - biomarkers

KW - contact allergy

KW - contact sensitization

U2 - 10.1111/cod.12789

DO - 10.1111/cod.12789

M3 - Review

C2 - 28497472

AN - SCOPUS:85018897672

SN - 0105-1873

VL - 77

SP - 1

EP - 16

JO - Contact Dermatitis

JF - Contact Dermatitis

IS - 1

ER -

Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis

Abstract

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