COX-1 inhibitory effect of medicinal plants of Ghana

Birgitte HV Larsen; Jens Soelberg; Anna Jäger

doi:10.1016/j.sajb.2015.04.004

COX-1 inhibitory effect of medicinal plants of Ghana

Birgitte HV Larsen, Jens Soelberg, Anna Jäger

7 Citations (Scopus)

Abstract

Plants used to treat inflammatory ailments, pain, fever and infections in Ghana, were tested for COX-1 inhibitory activity. Ethanolic extracts of 17 species were tested in a COX-1 assay. The extracts of Gardenia ternifolia, Thonningia sanguinea, Triumfetta rhomboidea, and the root of Zanthoxylum zanthoxyloides showed an inhibitory effect over 90% in the final concentration 0.1 μg/μL. The HPLC profiles indicated that the extracts of the four active species did not contain tannins. The observed in vitro activities support the use of some of the plant species in the traditional medicine system in Ghana.

Original language	English
Journal	South African Journal of Botany
Volume	99
Pages (from-to)	129-131
Number of pages	3
ISSN	0254-6299
DOIs	https://doi.org/10.1016/j.sajb.2015.04.004
Publication status	Published - 1 Jul 2015

Access to Document

10.1016/j.sajb.2015.04.004Licence: CC BY

Cite this

@article{77c74b605ce24a99aecd189a00c94fed,

title = "COX-1 inhibitory effect of medicinal plants of Ghana",

abstract = "Plants used to treat inflammatory ailments, pain, fever and infections in Ghana, were tested for COX-1 inhibitory activity. Ethanolic extracts of 17 species were tested in a COX-1 assay. The extracts of Gardenia ternifolia, Thonningia sanguinea, Triumfetta rhomboidea, and the root of Zanthoxylum zanthoxyloides showed an inhibitory effect over 90% in the final concentration 0.1 μg/μL. The HPLC profiles indicated that the extracts of the four active species did not contain tannins. The observed in vitro activities support the use of some of the plant species in the traditional medicine system in Ghana.",

author = "Larsen, {Birgitte HV} and Jens Soelberg and Anna J{\"a}ger",

year = "2015",

month = jul,

day = "1",

doi = "10.1016/j.sajb.2015.04.004",

language = "English",

volume = "99",

pages = "129--131",

journal = "South African Journal of Botany",

issn = "0254-6299",

publisher = "Elsevier",

}

TY - JOUR

T1 - COX-1 inhibitory effect of medicinal plants of Ghana

AU - Larsen, Birgitte HV

AU - Soelberg, Jens

AU - Jäger, Anna

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Plants used to treat inflammatory ailments, pain, fever and infections in Ghana, were tested for COX-1 inhibitory activity. Ethanolic extracts of 17 species were tested in a COX-1 assay. The extracts of Gardenia ternifolia, Thonningia sanguinea, Triumfetta rhomboidea, and the root of Zanthoxylum zanthoxyloides showed an inhibitory effect over 90% in the final concentration 0.1 μg/μL. The HPLC profiles indicated that the extracts of the four active species did not contain tannins. The observed in vitro activities support the use of some of the plant species in the traditional medicine system in Ghana.

AB - Plants used to treat inflammatory ailments, pain, fever and infections in Ghana, were tested for COX-1 inhibitory activity. Ethanolic extracts of 17 species were tested in a COX-1 assay. The extracts of Gardenia ternifolia, Thonningia sanguinea, Triumfetta rhomboidea, and the root of Zanthoxylum zanthoxyloides showed an inhibitory effect over 90% in the final concentration 0.1 μg/μL. The HPLC profiles indicated that the extracts of the four active species did not contain tannins. The observed in vitro activities support the use of some of the plant species in the traditional medicine system in Ghana.

U2 - 10.1016/j.sajb.2015.04.004

DO - 10.1016/j.sajb.2015.04.004

M3 - Journal article

SN - 0254-6299

VL - 99

SP - 129

EP - 131

JO - South African Journal of Botany

JF - South African Journal of Botany

ER -

COX-1 inhibitory effect of medicinal plants of Ghana

Abstract

Access to Document

Fingerprint

Cite this