COX-1 inhibitory effect of medicinal plants of Ghana

Birgitte HV Larsen; Jens Soelberg; Anna Jäger

doi:10.1016/j.sajb.2015.04.004

COX-1 inhibitory effect of medicinal plants of Ghana

Birgitte HV Larsen, Jens Soelberg, Anna Jäger

7 Citationer (Scopus)

Abstract

Plants used to treat inflammatory ailments, pain, fever and infections in Ghana, were tested for COX-1 inhibitory activity. Ethanolic extracts of 17 species were tested in a COX-1 assay. The extracts of Gardenia ternifolia, Thonningia sanguinea, Triumfetta rhomboidea, and the root of Zanthoxylum zanthoxyloides showed an inhibitory effect over 90% in the final concentration 0.1 μg/μL. The HPLC profiles indicated that the extracts of the four active species did not contain tannins. The observed in vitro activities support the use of some of the plant species in the traditional medicine system in Ghana.

Originalsprog	Engelsk
Tidsskrift	South African Journal of Botany
Vol/bind	99
Sider (fra-til)	129-131
Antal sider	3
ISSN	0254-6299
DOI	https://doi.org/10.1016/j.sajb.2015.04.004
Status	Udgivet - 1 jul. 2015

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10.1016/j.sajb.2015.04.004Licens: CC BY

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abstract = "Plants used to treat inflammatory ailments, pain, fever and infections in Ghana, were tested for COX-1 inhibitory activity. Ethanolic extracts of 17 species were tested in a COX-1 assay. The extracts of Gardenia ternifolia, Thonningia sanguinea, Triumfetta rhomboidea, and the root of Zanthoxylum zanthoxyloides showed an inhibitory effect over 90% in the final concentration 0.1 μg/μL. The HPLC profiles indicated that the extracts of the four active species did not contain tannins. The observed in vitro activities support the use of some of the plant species in the traditional medicine system in Ghana.",

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AU - Soelberg, Jens

AU - Jäger, Anna

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N2 - Plants used to treat inflammatory ailments, pain, fever and infections in Ghana, were tested for COX-1 inhibitory activity. Ethanolic extracts of 17 species were tested in a COX-1 assay. The extracts of Gardenia ternifolia, Thonningia sanguinea, Triumfetta rhomboidea, and the root of Zanthoxylum zanthoxyloides showed an inhibitory effect over 90% in the final concentration 0.1 μg/μL. The HPLC profiles indicated that the extracts of the four active species did not contain tannins. The observed in vitro activities support the use of some of the plant species in the traditional medicine system in Ghana.

AB - Plants used to treat inflammatory ailments, pain, fever and infections in Ghana, were tested for COX-1 inhibitory activity. Ethanolic extracts of 17 species were tested in a COX-1 assay. The extracts of Gardenia ternifolia, Thonningia sanguinea, Triumfetta rhomboidea, and the root of Zanthoxylum zanthoxyloides showed an inhibitory effect over 90% in the final concentration 0.1 μg/μL. The HPLC profiles indicated that the extracts of the four active species did not contain tannins. The observed in vitro activities support the use of some of the plant species in the traditional medicine system in Ghana.

U2 - 10.1016/j.sajb.2015.04.004

DO - 10.1016/j.sajb.2015.04.004

M3 - Journal article

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JO - South African Journal of Botany

JF - South African Journal of Botany

ER -

COX-1 inhibitory effect of medicinal plants of Ghana

Abstract

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