Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol

Lene Rørholm Pedersen; Rasmus Huan Olsen; Marianne Frederiksen; Arne Astrup; Elizaveta Chabanova; Philip Hasbak; Jens Juul Holst; Andreas Kjær; John W. Newman; Rosemary Walzem; Ulrik Wisløff; Ahmad Sajadieh; Steen Bendix Haugaard; Eva Prescott

doi:10.1186/1471-2261-13-106

Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol

Lene Rørholm Pedersen, Rasmus Huan Olsen, Marianne Frederiksen, Arne Astrup, Elizaveta Chabanova, Philip Hasbak, Jens Juul Holst, Andreas Kjær, John W. Newman, Rosemary Walzem, Ulrik Wisløff, Ahmad Sajadieh, Steen Bendix Haugaard, Eva Prescott

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Abstract

Background: Coronary artery disease (CAD) is accountable for more than 7 million deaths each year according to the World Health Organization (WHO). In a European population 80% of patients diagnosed with CAD are overweight and 31% are obese. Physical inactivity and overweight are major risk factors in CAD, thus central strategies in secondary prevention are increased physical activity and weight loss.Methods/Design: In a randomized controlled trial 70 participants with stable CAD, age 45-75, body mass index 28-40 kg/m² and no diabetes are randomized (1:1) to 12 weeks of intensive exercise or weight loss both succeeded by a 40-week follow-up. The exercise protocol consist of supervised aerobic interval training (AIT) at 85-90% of VO₂peak 3 times weekly for 12 weeks followed by supervised AIT twice weekly for 40 weeks. In the weight loss arm dieticians instruct the participants in a low energy diet (800-1000 kcal/day) for 12 weeks, followed by 40 weeks of weight maintenance combined with supervised AIT twice weekly. The primary endpoint of the study is change in coronary flow reserve after the first 12 weeks' intervention. Secondary endpoints include cardiovascular, metabolic, inflammatory and anthropometric measures.Discussion: The study will compare the short and long-term effects of a protocol consisting of AIT alone or a rapid weight loss followed by AIT. Additionally, it will provide new insight in mechanisms behind the benefits of exercise and weight loss. We wish to contribute to the creation of effective secondary prevention and sustainable rehabilitation strategies in the large population of overweight and obese patients diagnosed with CAD.Trial registration: ClinicalTrials.gov: NCT01724567.

Original language	English
Article number	106
Journal	B M C Cardiovascular Disorders
Volume	13
Issue number	1
Number of pages	8
ISSN	1471-2261
DOIs	https://doi.org/10.1186/1471-2261-13-106
Publication status	Published - 19 Nov 2013

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Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocolFinal published version, 442 KB

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Pedersen, L. R., Olsen, R. H., Frederiksen, M., Astrup, A., Chabanova, E., Hasbak, P., Holst, J. J., Kjær, A., Newman, J. W., Walzem, R., Wisløff, U., Sajadieh, A., Haugaard, S. B., & Prescott, E. (2013). Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol. B M C Cardiovascular Disorders, 13(1), Article 106. https://doi.org/10.1186/1471-2261-13-106

Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol. / Pedersen, Lene Rørholm; Olsen, Rasmus Huan; Frederiksen, Marianne et al.
In: B M C Cardiovascular Disorders, Vol. 13, No. 1, 106, 19.11.2013.

Research output: Contribution to journal › Journal article › Research › peer-review

Pedersen, LR, Olsen, RH, Frederiksen, M, Astrup, A, Chabanova, E, Hasbak, P, Holst, JJ , Kjær, A, Newman, JW, Walzem, R, Wisløff, U, Sajadieh, A , Haugaard, SB & Prescott, E 2013, 'Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol', B M C Cardiovascular Disorders, vol. 13, no. 1, 106. https://doi.org/10.1186/1471-2261-13-106

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abstract = "Background: Coronary artery disease (CAD) is accountable for more than 7 million deaths each year according to the World Health Organization (WHO). In a European population 80% of patients diagnosed with CAD are overweight and 31% are obese. Physical inactivity and overweight are major risk factors in CAD, thus central strategies in secondary prevention are increased physical activity and weight loss.Methods/Design: In a randomized controlled trial 70 participants with stable CAD, age 45-75, body mass index 28-40 kg/m2 and no diabetes are randomized (1:1) to 12 weeks of intensive exercise or weight loss both succeeded by a 40-week follow-up. The exercise protocol consist of supervised aerobic interval training (AIT) at 85-90% of VO2peak 3 times weekly for 12 weeks followed by supervised AIT twice weekly for 40 weeks. In the weight loss arm dieticians instruct the participants in a low energy diet (800-1000 kcal/day) for 12 weeks, followed by 40 weeks of weight maintenance combined with supervised AIT twice weekly. The primary endpoint of the study is change in coronary flow reserve after the first 12 weeks' intervention. Secondary endpoints include cardiovascular, metabolic, inflammatory and anthropometric measures.Discussion: The study will compare the short and long-term effects of a protocol consisting of AIT alone or a rapid weight loss followed by AIT. Additionally, it will provide new insight in mechanisms behind the benefits of exercise and weight loss. We wish to contribute to the creation of effective secondary prevention and sustainable rehabilitation strategies in the large population of overweight and obese patients diagnosed with CAD.Trial registration: ClinicalTrials.gov: NCT01724567.",

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T2 - the randomized CUT-IT trial protocol

AU - Pedersen, Lene Rørholm

AU - Olsen, Rasmus Huan

AU - Frederiksen, Marianne

AU - Astrup, Arne

AU - Chabanova, Elizaveta

AU - Hasbak, Philip

AU - Holst, Jens Juul

AU - Kjær, Andreas

AU - Newman, John W.

AU - Walzem, Rosemary

AU - Wisløff, Ulrik

AU - Sajadieh, Ahmad

AU - Haugaard, Steen Bendix

AU - Prescott, Eva

N1 - OA

PY - 2013/11/19

Y1 - 2013/11/19

N2 - Background: Coronary artery disease (CAD) is accountable for more than 7 million deaths each year according to the World Health Organization (WHO). In a European population 80% of patients diagnosed with CAD are overweight and 31% are obese. Physical inactivity and overweight are major risk factors in CAD, thus central strategies in secondary prevention are increased physical activity and weight loss.Methods/Design: In a randomized controlled trial 70 participants with stable CAD, age 45-75, body mass index 28-40 kg/m2 and no diabetes are randomized (1:1) to 12 weeks of intensive exercise or weight loss both succeeded by a 40-week follow-up. The exercise protocol consist of supervised aerobic interval training (AIT) at 85-90% of VO2peak 3 times weekly for 12 weeks followed by supervised AIT twice weekly for 40 weeks. In the weight loss arm dieticians instruct the participants in a low energy diet (800-1000 kcal/day) for 12 weeks, followed by 40 weeks of weight maintenance combined with supervised AIT twice weekly. The primary endpoint of the study is change in coronary flow reserve after the first 12 weeks' intervention. Secondary endpoints include cardiovascular, metabolic, inflammatory and anthropometric measures.Discussion: The study will compare the short and long-term effects of a protocol consisting of AIT alone or a rapid weight loss followed by AIT. Additionally, it will provide new insight in mechanisms behind the benefits of exercise and weight loss. We wish to contribute to the creation of effective secondary prevention and sustainable rehabilitation strategies in the large population of overweight and obese patients diagnosed with CAD.Trial registration: ClinicalTrials.gov: NCT01724567.

AB - Background: Coronary artery disease (CAD) is accountable for more than 7 million deaths each year according to the World Health Organization (WHO). In a European population 80% of patients diagnosed with CAD are overweight and 31% are obese. Physical inactivity and overweight are major risk factors in CAD, thus central strategies in secondary prevention are increased physical activity and weight loss.Methods/Design: In a randomized controlled trial 70 participants with stable CAD, age 45-75, body mass index 28-40 kg/m2 and no diabetes are randomized (1:1) to 12 weeks of intensive exercise or weight loss both succeeded by a 40-week follow-up. The exercise protocol consist of supervised aerobic interval training (AIT) at 85-90% of VO2peak 3 times weekly for 12 weeks followed by supervised AIT twice weekly for 40 weeks. In the weight loss arm dieticians instruct the participants in a low energy diet (800-1000 kcal/day) for 12 weeks, followed by 40 weeks of weight maintenance combined with supervised AIT twice weekly. The primary endpoint of the study is change in coronary flow reserve after the first 12 weeks' intervention. Secondary endpoints include cardiovascular, metabolic, inflammatory and anthropometric measures.Discussion: The study will compare the short and long-term effects of a protocol consisting of AIT alone or a rapid weight loss followed by AIT. Additionally, it will provide new insight in mechanisms behind the benefits of exercise and weight loss. We wish to contribute to the creation of effective secondary prevention and sustainable rehabilitation strategies in the large population of overweight and obese patients diagnosed with CAD.Trial registration: ClinicalTrials.gov: NCT01724567.

U2 - 10.1186/1471-2261-13-106

DO - 10.1186/1471-2261-13-106

M3 - Journal article

C2 - 24252596

SN - 1471-2261

VL - 13

JO - B M C Cardiovascular Disorders

JF - B M C Cardiovascular Disorders

IS - 1

M1 - 106

ER -

Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol

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