Abstract
In fission yeast, the COP9 signalosome is required to activate ribonucleotide reductase for DNA synthesis. This is mediated via the ubiquitin ligase Pcu4, activation of which leads to degradation of the scaffold protein Spd1, which anchors the small ribonucleotide reductase subunit in the nucleus away from the large subunit in the cytoplasm.
| Original language | English |
|---|---|
| Journal | Current Biology |
| Volume | 13 |
| Issue number | 14 |
| Pages (from-to) | R565-7 |
| ISSN | 0960-9822 |
| Publication status | Published - 15 Jul 2003 |
Keywords
- Cell Cycle
- Cullin Proteins
- Models, Biological
- Multiprotein Complexes
- Peptide Hydrolases
- Proteins
- Ribonucleotide Reductases
- Schizosaccharomyces
- Ubiquitin-Protein Ligases