COP9 signalosome: a provider of DNA building blocks

Olaf Nielsen

COP9 signalosome: a provider of DNA building blocks

Olaf Nielsen

Functional genomics

11 Citationer (Scopus)

717 Downloads (Pure)

Abstract

In fission yeast, the COP9 signalosome is required to activate ribonucleotide reductase for DNA synthesis. This is mediated via the ubiquitin ligase Pcu4, activation of which leads to degradation of the scaffold protein Spd1, which anchors the small ribonucleotide reductase subunit in the nucleus away from the large subunit in the cytoplasm.

Originalsprog	Engelsk
Tidsskrift	Current Biology
Vol/bind	13
Udgave nummer	14
Sider (fra-til)	R565-7
ISSN	0960-9822
Status	Udgivet - 15 jul. 2003

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title = "COP9 signalosome: a provider of DNA building blocks",

abstract = "In fission yeast, the COP9 signalosome is required to activate ribonucleotide reductase for DNA synthesis. This is mediated via the ubiquitin ligase Pcu4, activation of which leads to degradation of the scaffold protein Spd1, which anchors the small ribonucleotide reductase subunit in the nucleus away from the large subunit in the cytoplasm.",

keywords = "Cell Cycle, Cullin Proteins, Models, Biological, Multiprotein Complexes, Peptide Hydrolases, Proteins, Ribonucleotide Reductases, Schizosaccharomyces, Ubiquitin-Protein Ligases",

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AB - In fission yeast, the COP9 signalosome is required to activate ribonucleotide reductase for DNA synthesis. This is mediated via the ubiquitin ligase Pcu4, activation of which leads to degradation of the scaffold protein Spd1, which anchors the small ribonucleotide reductase subunit in the nucleus away from the large subunit in the cytoplasm.

KW - Cell Cycle

KW - Cullin Proteins

KW - Models, Biological

KW - Multiprotein Complexes

KW - Peptide Hydrolases

KW - Proteins

KW - Ribonucleotide Reductases

KW - Schizosaccharomyces

KW - Ubiquitin-Protein Ligases

M3 - Journal article

C2 - 12867051

SN - 0960-9822

VL - 13

SP - R565-7

JO - Current Biology

JF - Current Biology

IS - 14

ER -

COP9 signalosome: a provider of DNA building blocks

Abstract

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