Coordination of organ growth: principles and outstanding questions from the world of insects

D S Andersen; J Colombani; P Léopold

doi:10.1016/j.tcb.2013.03.005

Coordination of organ growth: principles and outstanding questions from the world of insects

69 Citations (Scopus)

Abstract

In animal species undergoing determinate growth, the making of a full-size adult body requires a series of coordinated growth events culminating in the cessation of growth that precedes sexual maturation. The merger between physiology and genetics now coming to pass in the Drosophila model allows us to decipher these growth events with an unsurpassed level of sophistication. Here, we review several coordination mechanisms that represent fundamental aspects of growth control: adaptation of growth to environmental cues, interorgan coordination, and the coordination of growth with developmental transitions. The view is emerging of an integrated process where organ-autonomous growth is coordinated with both developmental and environmental cues to define final body size.

Original language	English
Journal	Trends in Cell Biology
Volume	23
Issue number	7
Pages (from-to)	336-44
Number of pages	9
ISSN	0962-8924
DOIs	https://doi.org/10.1016/j.tcb.2013.03.005
Publication status	Published - Jul 2013
Externally published	Yes

Keywords

Animals
Drosophila/growth & development
Drosophila Proteins/metabolism
Ecdysone/metabolism
Fat Body/growth & development
Imaginal Discs/growth & development
Larva/growth & development
Models, Biological
Signal Transduction/physiology

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10.1016/j.tcb.2013.03.005

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title = "Coordination of organ growth: principles and outstanding questions from the world of insects",

abstract = "In animal species undergoing determinate growth, the making of a full-size adult body requires a series of coordinated growth events culminating in the cessation of growth that precedes sexual maturation. The merger between physiology and genetics now coming to pass in the Drosophila model allows us to decipher these growth events with an unsurpassed level of sophistication. Here, we review several coordination mechanisms that represent fundamental aspects of growth control: adaptation of growth to environmental cues, interorgan coordination, and the coordination of growth with developmental transitions. The view is emerging of an integrated process where organ-autonomous growth is coordinated with both developmental and environmental cues to define final body size. ",

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author = "Andersen, {D S} and J Colombani and P L{\'e}opold",

year = "2013",

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doi = "10.1016/j.tcb.2013.03.005",

language = "English",

volume = "23",

pages = "336--44",

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T1 - Coordination of organ growth

T2 - principles and outstanding questions from the world of insects

AU - Andersen, D S

AU - Colombani, J

AU - Léopold, P

PY - 2013/7

Y1 - 2013/7

N2 - In animal species undergoing determinate growth, the making of a full-size adult body requires a series of coordinated growth events culminating in the cessation of growth that precedes sexual maturation. The merger between physiology and genetics now coming to pass in the Drosophila model allows us to decipher these growth events with an unsurpassed level of sophistication. Here, we review several coordination mechanisms that represent fundamental aspects of growth control: adaptation of growth to environmental cues, interorgan coordination, and the coordination of growth with developmental transitions. The view is emerging of an integrated process where organ-autonomous growth is coordinated with both developmental and environmental cues to define final body size.

AB - In animal species undergoing determinate growth, the making of a full-size adult body requires a series of coordinated growth events culminating in the cessation of growth that precedes sexual maturation. The merger between physiology and genetics now coming to pass in the Drosophila model allows us to decipher these growth events with an unsurpassed level of sophistication. Here, we review several coordination mechanisms that represent fundamental aspects of growth control: adaptation of growth to environmental cues, interorgan coordination, and the coordination of growth with developmental transitions. The view is emerging of an integrated process where organ-autonomous growth is coordinated with both developmental and environmental cues to define final body size.

KW - Animals

KW - Drosophila/growth & development

KW - Drosophila Proteins/metabolism

KW - Ecdysone/metabolism

KW - Fat Body/growth & development

KW - Imaginal Discs/growth & development

KW - Larva/growth & development

KW - Models, Biological

KW - Signal Transduction/physiology

U2 - 10.1016/j.tcb.2013.03.005

DO - 10.1016/j.tcb.2013.03.005

M3 - Review

C2 - 23587490

SN - 0962-8924

VL - 23

SP - 336

EP - 344

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 7

ER -

Coordination of organ growth: principles and outstanding questions from the world of insects

Abstract

Keywords

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