Coordination of organ growth: principles and outstanding questions from the world of insects

D S Andersen; J Colombani; P Léopold

doi:10.1016/j.tcb.2013.03.005

Coordination of organ growth: principles and outstanding questions from the world of insects

69 Citationer (Scopus)

Abstract

In animal species undergoing determinate growth, the making of a full-size adult body requires a series of coordinated growth events culminating in the cessation of growth that precedes sexual maturation. The merger between physiology and genetics now coming to pass in the Drosophila model allows us to decipher these growth events with an unsurpassed level of sophistication. Here, we review several coordination mechanisms that represent fundamental aspects of growth control: adaptation of growth to environmental cues, interorgan coordination, and the coordination of growth with developmental transitions. The view is emerging of an integrated process where organ-autonomous growth is coordinated with both developmental and environmental cues to define final body size.

Originalsprog	Engelsk
Tidsskrift	Trends in Cell Biology
Vol/bind	23
Udgave nummer	7
Sider (fra-til)	336-44
Antal sider	9
ISSN	0962-8924
DOI	https://doi.org/10.1016/j.tcb.2013.03.005
Status	Udgivet - jul. 2013
Udgivet eksternt	Ja

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10.1016/j.tcb.2013.03.005

Citationsformater

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abstract = "In animal species undergoing determinate growth, the making of a full-size adult body requires a series of coordinated growth events culminating in the cessation of growth that precedes sexual maturation. The merger between physiology and genetics now coming to pass in the Drosophila model allows us to decipher these growth events with an unsurpassed level of sophistication. Here, we review several coordination mechanisms that represent fundamental aspects of growth control: adaptation of growth to environmental cues, interorgan coordination, and the coordination of growth with developmental transitions. The view is emerging of an integrated process where organ-autonomous growth is coordinated with both developmental and environmental cues to define final body size. ",

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author = "Andersen, {D S} and J Colombani and P L{\'e}opold",

year = "2013",

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doi = "10.1016/j.tcb.2013.03.005",

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T2 - principles and outstanding questions from the world of insects

AU - Andersen, D S

AU - Colombani, J

AU - Léopold, P

PY - 2013/7

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N2 - In animal species undergoing determinate growth, the making of a full-size adult body requires a series of coordinated growth events culminating in the cessation of growth that precedes sexual maturation. The merger between physiology and genetics now coming to pass in the Drosophila model allows us to decipher these growth events with an unsurpassed level of sophistication. Here, we review several coordination mechanisms that represent fundamental aspects of growth control: adaptation of growth to environmental cues, interorgan coordination, and the coordination of growth with developmental transitions. The view is emerging of an integrated process where organ-autonomous growth is coordinated with both developmental and environmental cues to define final body size.

AB - In animal species undergoing determinate growth, the making of a full-size adult body requires a series of coordinated growth events culminating in the cessation of growth that precedes sexual maturation. The merger between physiology and genetics now coming to pass in the Drosophila model allows us to decipher these growth events with an unsurpassed level of sophistication. Here, we review several coordination mechanisms that represent fundamental aspects of growth control: adaptation of growth to environmental cues, interorgan coordination, and the coordination of growth with developmental transitions. The view is emerging of an integrated process where organ-autonomous growth is coordinated with both developmental and environmental cues to define final body size.

KW - Animals

KW - Drosophila/growth & development

KW - Drosophila Proteins/metabolism

KW - Ecdysone/metabolism

KW - Fat Body/growth & development

KW - Imaginal Discs/growth & development

KW - Larva/growth & development

KW - Models, Biological

KW - Signal Transduction/physiology

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DO - 10.1016/j.tcb.2013.03.005

M3 - Review

C2 - 23587490

SN - 0962-8924

VL - 23

SP - 336

EP - 344

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 7

ER -

Coordination of organ growth: principles and outstanding questions from the world of insects

Abstract

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