Consensus Paper: Probing Homeostatic Plasticity of Human Cortex With Non-invasive Transcranial Brain Stimulation

TY - JOUR

T1 - Consensus Paper

T2 - Probing Homeostatic Plasticity of Human Cortex With Non-invasive Transcranial Brain Stimulation

AU - Karabanov, Anke

AU - Ziemann, Ulf

AU - Hamada, Masashi

AU - George, Mark S

AU - Quartarone, Angelo

AU - Classen, Joseph

AU - Massimini, Marcello

AU - Rothwell, John

AU - Siebner, Hartwig Roman

N1 - Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2015

Y1 - 2015

N2 - Homeostatic plasticity is thought to stabilize neural activity around a set point within a physiologically reasonable dynamic range. Over the last ten years, a wide range of non-invasive transcranial brain stimulation (NTBS) techniques have been used to probe homeostatic control of cortical plasticity in the intact human brain. Here, we review different NTBS approaches to study homeostatic plasticity on a systems level and relate the findings to both, physiological evidence from in vitro studies and to a theoretical framework of homeostatic function. We highlight differences between homeostatic and other non-homeostatic forms of plasticity and we examine the contribution of sleep in restoring synaptic homeostasis. Finally, we discuss the growing number of studies showing that abnormal homeostatic plasticity may be associated to a range of neuropsychiatric diseases.

AB - Homeostatic plasticity is thought to stabilize neural activity around a set point within a physiologically reasonable dynamic range. Over the last ten years, a wide range of non-invasive transcranial brain stimulation (NTBS) techniques have been used to probe homeostatic control of cortical plasticity in the intact human brain. Here, we review different NTBS approaches to study homeostatic plasticity on a systems level and relate the findings to both, physiological evidence from in vitro studies and to a theoretical framework of homeostatic function. We highlight differences between homeostatic and other non-homeostatic forms of plasticity and we examine the contribution of sleep in restoring synaptic homeostasis. Finally, we discuss the growing number of studies showing that abnormal homeostatic plasticity may be associated to a range of neuropsychiatric diseases.

KW - Brain

KW - Cerebral Cortex

KW - Consensus

KW - Homeostasis

KW - Humans

KW - Motor Cortex

KW - Nerve Net

KW - Neuronal Plasticity

KW - Transcranial Direct Current Stimulation

U2 - 10.1016/j.brs.2015.01.404

DO - 10.1016/j.brs.2015.01.404

M3 - Review

C2 - 26050599

SN - 1935-861X

VL - 8

SP - 442

EP - 454

JO - Brain Stimulation

JF - Brain Stimulation

IS - 3

ER -