Abstract
Adult stem cells (ASCs) are tissue resident stem cells responsible for tissue homeostasis and regeneration following injury. In uninjured tissues, ASCs exist in a nonproliferating, reversibly cell cycle-arrested state known as quiescence or G0. A key function of the quiescent state is to preserve stemness in ASCs by preventing precocious differentiation, and thus maintaining a pool of undifferentiated ASCs. Recent evidences suggest that quiescence is an actively maintained state and that excessive or defective quiescence may lead to compromised tissue regeneration or tumorigenesis. The aim of this review is to provide an update regarding the biological mechanisms of ASC quiescence and their role in tissue regeneration.
| Original language | English |
|---|---|
| Journal | Stem Cells |
| Volume | 33 |
| Issue number | 10 |
| Pages (from-to) | 2903-12 |
| Number of pages | 10 |
| ISSN | 1066-5099 |
| DOIs | |
| Publication status | Published - 1 Oct 2015 |
Keywords
- Adult Stem Cells
- Cell Cycle Checkpoints
- Cell Differentiation
- Homeostasis
- Humans
- Regeneration
- Wound Healing
- Journal Article
- Research Support, Non-U.S. Gov't
- Review