Concise Review: Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration

Mohammad Rumman; Jyotsna Dhawan; Moustapha Kassem

doi:10.1002/stem.2056

Concise Review: Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration

Mohammad Rumman, Jyotsna Dhawan, Moustapha Kassem

DanStem

83 Citationer (Scopus)

Abstract

Adult stem cells (ASCs) are tissue resident stem cells responsible for tissue homeostasis and regeneration following injury. In uninjured tissues, ASCs exist in a nonproliferating, reversibly cell cycle-arrested state known as quiescence or G0. A key function of the quiescent state is to preserve stemness in ASCs by preventing precocious differentiation, and thus maintaining a pool of undifferentiated ASCs. Recent evidences suggest that quiescence is an actively maintained state and that excessive or defective quiescence may lead to compromised tissue regeneration or tumorigenesis. The aim of this review is to provide an update regarding the biological mechanisms of ASC quiescence and their role in tissue regeneration.

Originalsprog	Engelsk
Tidsskrift	Stem Cells
Vol/bind	33
Udgave nummer	10
Sider (fra-til)	2903-12
Antal sider	10
ISSN	1066-5099
DOI	https://doi.org/10.1002/stem.2056
Status	Udgivet - 1 okt. 2015

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10.1002/stem.2056

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Citationsformater

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AB - Adult stem cells (ASCs) are tissue resident stem cells responsible for tissue homeostasis and regeneration following injury. In uninjured tissues, ASCs exist in a nonproliferating, reversibly cell cycle-arrested state known as quiescence or G0. A key function of the quiescent state is to preserve stemness in ASCs by preventing precocious differentiation, and thus maintaining a pool of undifferentiated ASCs. Recent evidences suggest that quiescence is an actively maintained state and that excessive or defective quiescence may lead to compromised tissue regeneration or tumorigenesis. The aim of this review is to provide an update regarding the biological mechanisms of ASC quiescence and their role in tissue regeneration.

KW - Adult Stem Cells

KW - Cell Cycle Checkpoints

KW - Cell Differentiation

KW - Homeostasis

KW - Humans

KW - Regeneration

KW - Wound Healing

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Concise Review: Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration

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