Computed Tomography (CT) Perfusion in Abdominal Cancer: Technical Aspects

Martin Lundsgaard Hansen; Rikke Norling; Carsten Lauridsen; Eva Marie Fallentin; Lene Bæksgaard Jensen; Klaus Fuglsang Kofoed; Lars Bo Svendsen; Michael Bachmann Nielsen

doi:10.3390/diagnostics3020261

Computed Tomography (CT) Perfusion in Abdominal Cancer: Technical Aspects

Martin Lundsgaard Hansen, Rikke Norling, Carsten Lauridsen, Eva Marie Fallentin, Lene Bæksgaard Jensen, Klaus Fuglsang Kofoed, Lars Bo Svendsen, Michael Bachmann Nielsen

Department of Clinical Medicine

Abstract

Computed Tomography (CT) Perfusion is an evolving method to visualize perfusion in organs and tissue. With the introduction of multidetector CT scanners, it is now possible to cover up to 16 cm in one rotation, and thereby making it possible to scan entire organs such as the liver with a fixed table position. Advances in reconstruction algorithms make it possible to reduce the radiation dose for each examination to acceptable levels. Regarding abdominal imaging, CT perfusion is still considered a research tool, but several studies have proven it as a reliable non-invasive technique for assessment of vascularity. CT perfusion has also been used for tumor characterization, staging of disease, response evaluation of newer drugs targeted towards angiogenesis and as a method for early detection of recurrence after radiation and embolization. There are several software solutions available on the market today based on different perfusion algorithms. However, there is no consensus on which protocol and algorithm to use for specific organs. In this OPEN article, the authors give an introduction to CT perfusion in abdominal imaging introducing technical aspects for calculation of perfusion parameters, and considerations on patient preparation. This article also contains clinical cases to illustrate the use of C perfusion in abdominal imaging.

Original language	English
Journal	Diagnostics
Volume	3
Pages (from-to)	261-270
Number of pages	10
ISSN	2075-4418
DOIs	https://doi.org/10.3390/diagnostics3020261
Publication status	Published - Jun 2013

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@article{54102340515946f8b0ade4143b1e9278,

title = "Computed Tomography (CT) Perfusion in Abdominal Cancer: Technical Aspects",

abstract = "Computed Tomography (CT) Perfusion is an evolving method to visualize perfusion in organs and tissue. With the introduction of multidetector CT scanners, it is now possible to cover up to 16 cm in one rotation, and thereby making it possible to scan entire organs such as the liver with a fixed table position. Advances in reconstruction algorithms make it possible to reduce the radiation dose for each examination to acceptable levels. Regarding abdominal imaging, CT perfusion is still considered a research tool, but several studies have proven it as a reliable non-invasive technique for assessment of vascularity. CT perfusion has also been used for tumor characterization, staging of disease, response evaluation of newer drugs targeted towards angiogenesis and as a method for early detection of recurrence after radiation and embolization. There are several software solutions available on the market today based on different perfusion algorithms. However, there is no consensus on which protocol and algorithm to use for specific organs. In this OPEN article, the authors give an introduction to CT perfusion in abdominal imaging introducing technical aspects for calculation of perfusion parameters, and considerations on patient preparation. This article also contains clinical cases to illustrate the use of C perfusion in abdominal imaging.",

author = "Hansen, {Martin Lundsgaard} and Rikke Norling and Carsten Lauridsen and Fallentin, {Eva Marie} and Jensen, {Lene B{\ae}ksgaard} and Kofoed, {Klaus Fuglsang} and Svendsen, {Lars Bo} and Nielsen, {Michael Bachmann}",

year = "2013",

month = jun,

doi = "10.3390/diagnostics3020261",

language = "English",

volume = "3",

pages = "261--270",

journal = "Diagnostics",

issn = "2075-4418",

publisher = "MDPI AG",

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TY - JOUR

T1 - Computed Tomography (CT) Perfusion in Abdominal Cancer

T2 - Technical Aspects

AU - Hansen, Martin Lundsgaard

AU - Norling, Rikke

AU - Lauridsen, Carsten

AU - Fallentin, Eva Marie

AU - Jensen, Lene Bæksgaard

AU - Kofoed, Klaus Fuglsang

AU - Svendsen, Lars Bo

AU - Nielsen, Michael Bachmann

PY - 2013/6

Y1 - 2013/6

N2 - Computed Tomography (CT) Perfusion is an evolving method to visualize perfusion in organs and tissue. With the introduction of multidetector CT scanners, it is now possible to cover up to 16 cm in one rotation, and thereby making it possible to scan entire organs such as the liver with a fixed table position. Advances in reconstruction algorithms make it possible to reduce the radiation dose for each examination to acceptable levels. Regarding abdominal imaging, CT perfusion is still considered a research tool, but several studies have proven it as a reliable non-invasive technique for assessment of vascularity. CT perfusion has also been used for tumor characterization, staging of disease, response evaluation of newer drugs targeted towards angiogenesis and as a method for early detection of recurrence after radiation and embolization. There are several software solutions available on the market today based on different perfusion algorithms. However, there is no consensus on which protocol and algorithm to use for specific organs. In this OPEN article, the authors give an introduction to CT perfusion in abdominal imaging introducing technical aspects for calculation of perfusion parameters, and considerations on patient preparation. This article also contains clinical cases to illustrate the use of C perfusion in abdominal imaging.

AB - Computed Tomography (CT) Perfusion is an evolving method to visualize perfusion in organs and tissue. With the introduction of multidetector CT scanners, it is now possible to cover up to 16 cm in one rotation, and thereby making it possible to scan entire organs such as the liver with a fixed table position. Advances in reconstruction algorithms make it possible to reduce the radiation dose for each examination to acceptable levels. Regarding abdominal imaging, CT perfusion is still considered a research tool, but several studies have proven it as a reliable non-invasive technique for assessment of vascularity. CT perfusion has also been used for tumor characterization, staging of disease, response evaluation of newer drugs targeted towards angiogenesis and as a method for early detection of recurrence after radiation and embolization. There are several software solutions available on the market today based on different perfusion algorithms. However, there is no consensus on which protocol and algorithm to use for specific organs. In this OPEN article, the authors give an introduction to CT perfusion in abdominal imaging introducing technical aspects for calculation of perfusion parameters, and considerations on patient preparation. This article also contains clinical cases to illustrate the use of C perfusion in abdominal imaging.

U2 - 10.3390/diagnostics3020261

DO - 10.3390/diagnostics3020261

M3 - Journal article

SN - 2075-4418

VL - 3

SP - 261

EP - 270

JO - Diagnostics

JF - Diagnostics

ER -

Computed Tomography (CT) Perfusion in Abdominal Cancer: Technical Aspects

Abstract

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