Comparison study of two different procedures for the determination of drugs of abuse in postmortem brain samples

Karen Marie Dollerup Holm, Birgit Reiter, Louise Skov, Thomas Stimpfl

Abstract

The aim of this study was to compare two routine solid phase extraction methods for the analysis of body-fluids and tissue samples; a routine method developed in Vienna for tissue samples compared to a routine method developed in Copenhagen for blood. Our approach was to simply exchange the matrix from blood to brain and thereby see if we could avoid a time comsuming optimization of the Copenhagen method to accommodate the more complex brain matrix. Comparative analyses and quantification of eight drugs of abuse (methadone, morphine, amphetamine, benzoylecgonine, cocaine, morphine, codeine, diazepam and 7-aminoflunitrazepam) in 19 brain homogenates of authentic cases were conducted.
Original languageEnglish
JournalTIAFT Bulletin
Volume44
Issue number1
Pages (from-to)26-30
Number of pages5
ISSN1080-9945
Publication statusPublished - May 2014

Fingerprint

Dive into the research topics of 'Comparison study of two different procedures for the determination of drugs of abuse in postmortem brain samples'. Together they form a unique fingerprint.

Cite this