Comparison study of two different procedures for the determination of drugs of abuse in postmortem brain samples

TY - JOUR

T1 - Comparison study of two different procedures for the determination of drugs of abuse in postmortem brain samples

AU - Holm, Karen Marie Dollerup

AU - Reiter, Birgit

AU - Skov, Louise

AU - Stimpfl, Thomas

PY - 2014/5

Y1 - 2014/5

N2 - The aim of this study was to compare two routine solid phase extraction methods for the analysis of body-fluids and tissue samples; a routine method developed in Vienna for tissue samples compared to a routine method developed in Copenhagen for blood. Our approach was to simply exchange the matrix from blood to brain and thereby see if we could avoid a time comsuming optimization of the Copenhagen method to accommodate the more complex brain matrix. Comparative analyses and quantification of eight drugs of abuse (methadone, morphine, amphetamine, benzoylecgonine, cocaine, morphine, codeine, diazepam and 7-aminoflunitrazepam) in 19 brain homogenates of authentic cases were conducted.

AB - The aim of this study was to compare two routine solid phase extraction methods for the analysis of body-fluids and tissue samples; a routine method developed in Vienna for tissue samples compared to a routine method developed in Copenhagen for blood. Our approach was to simply exchange the matrix from blood to brain and thereby see if we could avoid a time comsuming optimization of the Copenhagen method to accommodate the more complex brain matrix. Comparative analyses and quantification of eight drugs of abuse (methadone, morphine, amphetamine, benzoylecgonine, cocaine, morphine, codeine, diazepam and 7-aminoflunitrazepam) in 19 brain homogenates of authentic cases were conducted.

M3 - Journal article

SN - 1080-9945

VL - 44

SP - 26

EP - 30

JO - TIAFT Bulletin

JF - TIAFT Bulletin

IS - 1

ER -