Combinations of isocitrate and citrate enhance calcium salt solubility and supersaturation robustness

Hong Cheng; André Castilho Garcia; Ning Tang; Bente Pia Danielsen; Leif Horsfelt Skibsted

doi:10.1016/j.idairyj.2018.06.009

Combinations of isocitrate and citrate enhance calcium salt solubility and supersaturation robustness

Hong Cheng, André Castilho Garcia, Ning Tang, Bente Pia Danielsen, Leif Horsfelt Skibsted

6 Citations (Scopus)

Abstract

Calcium isocitrate tetrahydrate was characterised and found to be less soluble in water than calcium citrate tetrahydrate. The solubilities of both decrease with temperature, but increase with pressure. Calcium binds isocitrate with a constant of K_a = (6.80 ± 0.05) × 10³ (ΔH° = −22.1 ± 2.6 kJ mol⁻¹; ΔS° = −6.7 ± 8.7 J mol⁻¹ K⁻¹). The solubility product is K_sp = (8.7 ± 0.08) × 10⁻¹⁷ (ΔH° = 30.1 ± 2.2 kJ mol⁻¹; ΔS° = −206 ± 7 J mol⁻¹ K⁻¹). Calcium isocitrate dissolves in aqueous sodium citrate, spontaneously forming solutions supersaturated in calcium citrate by a factor of at least two for 0.50 mol L⁻¹ sodium citrate from which precipitation initiates after 20 h. Calcium citrate dissolves under similar conditions in sodium isocitrate forming supersaturated solutions in calcium isocitrate without precipitation for months. Slow crystallisation kinetics of calcium isocitrate explains the supersaturation robustness for combinations of calcium citrate and sodium isocitrate inspiring for formulation of whey mineral products.

Original language	English
Journal	International Dairy Journal
Volume	85
Pages (from-to)	225-236
Number of pages	12
ISSN	0958-6946
DOIs	https://doi.org/10.1016/j.idairyj.2018.06.009
Publication status	Published - Oct 2018

Access to Document

10.1016/j.idairyj.2018.06.009

Cite this

@article{aa1a084882584a5cb60e781ab08a7371,

title = "Combinations of isocitrate and citrate enhance calcium salt solubility and supersaturation robustness",

abstract = "Calcium isocitrate tetrahydrate was characterised and found to be less soluble in water than calcium citrate tetrahydrate. The solubilities of both decrease with temperature, but increase with pressure. Calcium binds isocitrate with a constant of Ka = (6.80 ± 0.05) × 103 (ΔH° = −22.1 ± 2.6 kJ mol−1; ΔS° = −6.7 ± 8.7 J mol−1 K−1). The solubility product is Ksp = (8.7 ± 0.08) × 10−17 (ΔH° = 30.1 ± 2.2 kJ mol−1; ΔS° = −206 ± 7 J mol−1 K−1). Calcium isocitrate dissolves in aqueous sodium citrate, spontaneously forming solutions supersaturated in calcium citrate by a factor of at least two for 0.50 mol L−1 sodium citrate from which precipitation initiates after 20 h. Calcium citrate dissolves under similar conditions in sodium isocitrate forming supersaturated solutions in calcium isocitrate without precipitation for months. Slow crystallisation kinetics of calcium isocitrate explains the supersaturation robustness for combinations of calcium citrate and sodium isocitrate inspiring for formulation of whey mineral products.",

author = "Hong Cheng and Garcia, {Andr{\'e} Castilho} and Ning Tang and Danielsen, {Bente Pia} and Skibsted, {Leif Horsfelt}",

year = "2018",

month = oct,

doi = "10.1016/j.idairyj.2018.06.009",

language = "English",

volume = "85",

pages = "225--236",

journal = "International Dairy Journal",

issn = "0958-6946",

publisher = "Elsevier",

}

TY - JOUR

T1 - Combinations of isocitrate and citrate enhance calcium salt solubility and supersaturation robustness

AU - Cheng, Hong

AU - Garcia, André Castilho

AU - Tang, Ning

AU - Danielsen, Bente Pia

AU - Skibsted, Leif Horsfelt

PY - 2018/10

Y1 - 2018/10

N2 - Calcium isocitrate tetrahydrate was characterised and found to be less soluble in water than calcium citrate tetrahydrate. The solubilities of both decrease with temperature, but increase with pressure. Calcium binds isocitrate with a constant of Ka = (6.80 ± 0.05) × 103 (ΔH° = −22.1 ± 2.6 kJ mol−1; ΔS° = −6.7 ± 8.7 J mol−1 K−1). The solubility product is Ksp = (8.7 ± 0.08) × 10−17 (ΔH° = 30.1 ± 2.2 kJ mol−1; ΔS° = −206 ± 7 J mol−1 K−1). Calcium isocitrate dissolves in aqueous sodium citrate, spontaneously forming solutions supersaturated in calcium citrate by a factor of at least two for 0.50 mol L−1 sodium citrate from which precipitation initiates after 20 h. Calcium citrate dissolves under similar conditions in sodium isocitrate forming supersaturated solutions in calcium isocitrate without precipitation for months. Slow crystallisation kinetics of calcium isocitrate explains the supersaturation robustness for combinations of calcium citrate and sodium isocitrate inspiring for formulation of whey mineral products.

AB - Calcium isocitrate tetrahydrate was characterised and found to be less soluble in water than calcium citrate tetrahydrate. The solubilities of both decrease with temperature, but increase with pressure. Calcium binds isocitrate with a constant of Ka = (6.80 ± 0.05) × 103 (ΔH° = −22.1 ± 2.6 kJ mol−1; ΔS° = −6.7 ± 8.7 J mol−1 K−1). The solubility product is Ksp = (8.7 ± 0.08) × 10−17 (ΔH° = 30.1 ± 2.2 kJ mol−1; ΔS° = −206 ± 7 J mol−1 K−1). Calcium isocitrate dissolves in aqueous sodium citrate, spontaneously forming solutions supersaturated in calcium citrate by a factor of at least two for 0.50 mol L−1 sodium citrate from which precipitation initiates after 20 h. Calcium citrate dissolves under similar conditions in sodium isocitrate forming supersaturated solutions in calcium isocitrate without precipitation for months. Slow crystallisation kinetics of calcium isocitrate explains the supersaturation robustness for combinations of calcium citrate and sodium isocitrate inspiring for formulation of whey mineral products.

U2 - 10.1016/j.idairyj.2018.06.009

DO - 10.1016/j.idairyj.2018.06.009

M3 - Journal article

SN - 0958-6946

VL - 85

SP - 225

EP - 236

JO - International Dairy Journal

JF - International Dairy Journal

ER -

Combinations of isocitrate and citrate enhance calcium salt solubility and supersaturation robustness

Abstract

Access to Document

Fingerprint

Cite this